Target Information
| Target General Infomation | |||||
|---|---|---|---|---|---|
| Target ID |
T65116
|
||||
| Former ID |
TTDR01229
|
||||
| Target Name |
5'-Nucleotidase
|
||||
| Gene Name |
NT5E
|
||||
| Synonyms |
5'-NT; CD73 antigen; Ecto-5'-nucleotidase; NT5E
|
||||
| Target Type |
Research
|
||||
| Function |
Hydrolyzes extracellular nucleotides into membrane permeable nucleosides. Exhibits AMP-, NAD-, and NMN-nucleosidase activities.
|
||||
| BioChemical Class |
Phosphoric monoester hydrolases
|
||||
| Target Validation |
T65116
|
||||
| UniProt ID | |||||
| EC Number |
EC 3.1.3.5
|
||||
| Sequence |
MCPRAARAPATLLLALGAVLWPAAGAWELTILHTNDVHSRLEQTSEDSSKCVNASRCMGG
VARLFTKVQQIRRAEPNVLLLDAGDQYQGTIWFTVYKGAEVAHFMNALRYDAMALGNHEF DNGVEGLIEPLLKEAKFPILSANIKAKGPLASQISGLYLPYKVLPVGDEVVGIVGYTSKE TPFLSNPGTNLVFEDEITALQPEVDKLKTLNVNKIIALGHSGFEMDKLIAQKVRGVDVVV GGHSNTFLYTGNPPSKEVPAGKYPFIVTSDDGRKVPVVQAYAFGKYLGYLKIEFDERGNV ISSHGNPILLNSSIPEDPSIKADINKWRIKLDNYSTQELGKTIVYLDGSSQSCRFRECNM GNLICDAMINNNLRHTDEMFWNHVSMCILNGGGIRSPIDERNNGTITWENLAAVLPFGGT FDLVQLKGSTLKKAFEHSVHRYGQSTGEFLQVGGIHVVYDLSRKPGDRVVKLDVLCTKCR VPSYDPLKMDEVYKVILPNFLANGGDGFQMIKDELLRHDSGDQDINVVSTYISKMKVIYP AVEGRIKFSTGSHCHGSFSLIFLSLWAVIFVLYQ |
||||
| Target Expression Profile (TEP) and Drug Resistance Mutation (DRM) | |||||
| TEP | EXP Info | ||||
| Pathways | |||||
| BioCyc Pathway | Purine nucleotides degradation | ||||
| Urate biosynthesis/inosine 5' | |||||
| -phosphate degradation | |||||
| Adenosine nucleotides degradation | |||||
| KEGG Pathway | Purine metabolism | ||||
| Pyrimidine metabolism | |||||
| Nicotinate and nicotinamide metabolism | |||||
| Metabolic pathways | |||||
| PANTHER Pathway | Purine metabolism | ||||
| Pyrimidine Metabolism | |||||
| Pathway Interaction Database | HIF-1-alpha transcription factor network | ||||
| Reactome | Purine catabolism | ||||
| WikiPathways | Differentiation Pathway | ||||
| miR-targeted genes in muscle cell - TarBase | |||||
| miR-targeted genes in lymphocytes - TarBase | |||||
| miR-targeted genes in epithelium - TarBase | |||||
| Metabolism of nucleotides | |||||
| References | |||||
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.