Target Information

Target General Infomation
Target ID
T72038
Former ID
TTDR00804
Target Name
Galectin-3
Gene Name
LGALS3
Synonyms
35 kDa lectin; Beta-galactoside-binding protein LGALS3; CBP 35; Carbohydrate binding protein 35; GALBP; Galactose-specific lectin 3; Galactoside-binding protein; IgE-binding protein; L-31; Laminin-binding protein; Lectin L-29; Mac-2 antigen; LGALS3
Target Type
Clinical Trial
Disease Melanoma [ICD9: 172; ICD10: C43]
Function
Galactose-specific lectin which binds IgE. May mediate with the alpha-3, beta-1 integrin the stimulation by CSPG4 of endothelial cells migration. Together with DMBT1, required for terminal differentiation of columnar epithelial cells during early embryogenesis (By similarity). In the nucleus: acts as a pre-mRNA splicing factor. Involved in acute inflammatory responses including neutrophil activation and adhesion, chemoattraction of monocytes macrophages, opsonization of apoptotic neutrophils, and activation of mast cells.
UniProt ID
P17931
Sequence
MADNFSLHDALSGSGNPNPQGWPGAWGNQPAGAGGYPGASYPGAYPGQAPPGAYPGQAPP
GAYPGAPGAYPGAPAPGVYPGPPSGPGAYPSSGQPSATGAYPATGPYGAPAGPLIVPYNL
PLPGGVVPRMLITILGTVKPNANRIALDFQRGNDVAFHFNPRFNENNRRVIVCNTKLDNN
WGREERQSVFPFESGKPFKIQVLVEPDHFKVAVNDAHLLQYNHRVKKLNEISKLGISGDI
DLTSASYTMI
Drugs and Mode of Action
Drug(s) GR-MD-02 Drug Info Phase 2 Melanoma [525159]
Inhibitor 2,3,5,6-Tetrafluoro-4-Methoxy-Benzamide Drug Info [551393]
GR-MD-02 Drug Info [532604]
PFFFFF Drug Info [528518]
Target Expression Profile (TEP) and Drug Resistance Mutation (DRM)
TEP EXP Info
Pathways
NetPath Pathway TGF_beta_Receptor Signaling Pathway
Pathway Interaction Database Hedgehog signaling events mediated by Gli proteins
Regulation of Ras family activation
Reactome Advanced glycosylation endproduct receptor signaling
WikiPathways Spinal Cord Injury
AGE/RAGE pathway
Advanced glycosylation endproduct receptor signaling
References
Ref 525159ClinicalTrials.gov (NCT02421094) Clinical Study for Non-Invasive Imaging Methods for GR-MD-02 for Treatment of Liver Fibrosis. U.S. National Institutes of Health.
Ref 528518Bioorg Med Chem Lett. 2007 Feb 1;17(3):793-8. Epub 2006 Oct 27.Discovery of galectin ligands in fully randomized combinatorial one-bead-one-compound (glyco)peptide libraries.
Ref 532604Therapy of experimental NASH and fibrosis with galectin inhibitors. PLoS One. 2013 Dec 18;8(12):e83481.
Ref 551393How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6.

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