Target Information
| Target General Infomation | |||||
|---|---|---|---|---|---|
| Target ID |
T92458
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| Former ID |
TTDI02046
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| Target Name |
Cytochrome P450 24
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| Gene Name |
CYP24A1
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| Synonyms |
1,25dihydroxyvitamin D(3) 24hydroxylase, mitochondrial; 24OHase; Cytochrome P450CC24; Vitamin D(3) 24hydroxylase; CYP24A1
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| Target Type |
Clinical Trial
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| Disease | Psoriasis [ICD9: 696; ICD10: L40] | ||||
| Function |
Has a role in maintaining calcium homeostasis. Catalyzes the NADPH-dependent 24-hydroxylation of calcidiol (25- hydroxyvitamin D(3)) and calcitriol (1-alpha,25-dihydroxyvitamin D(3)). The enzyme can perform up to 6 rounds of hydroxylation of calcitriol leading to calcitroic acid. It also shows 23- hydroxylating activity leading to 1-alpha,25-dihydroxyvitamin D(3)-26,23-lactone as end product.
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| BioChemical Class |
Oxidoreductases acting on paired donors
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| UniProt ID | |||||
| EC Number |
EC 1.14.13.126
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| Sequence |
MSSPISKSRSLAAFLQQLRSPRQPPRLVTSTAYTSPQPREVPVCPLTAGGETQNAAALPG
PTSWPLLGSLLQILWKGGLKKQHDTLVEYHKKYGKIFRMKLGSFESVHLGSPCLLEALYR TESAYPQRLEIKPWKAYRDYRKEGYGLLILEGEDWQRVRSAFQKKLMKPGEVMKLDNKIN EVLADFMGRIDELCDERGHVEDLYSELNKWSFESICLVLYEKRFGLLQKNAGDEAVNFIM AIKTMMSTFGRMMVTPVELHKSLNTKVWQDHTLAWDTIFKSVKACIDNRLEKYSQQPSAD FLCDIYHQNRLSKKELYAAVTELQLAAVETTANSLMWILYNLSRNPQVQQKLLKEIQSVL PENQVPRAEDLRNMPYLKACLKESMRLTPSVPFTTRTLDKATVLGEYALPKGTVLMLNTQ VLGSSEDNFEDSSQFRPERWLQEKEKINPFAHLPFGVGKRMCIGRRLAELQLHLALCWIV RKYDIQATDNEPVEMLHSGTLVPSRELPIAFCQR |
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| Drugs and Mode of Action | |||||
| Target Expression Profile (TEP) and Drug Resistance Mutation (DRM) | |||||
| TEP | EXP Info | ||||
| Pathways | |||||
| KEGG Pathway | Steroid biosynthesis | ||||
| Metabolic pathways | |||||
| MicroRNAs in cancer | |||||
| NetPath Pathway | TGF_beta_Receptor Signaling Pathway | ||||
| PANTHER Pathway | Vitamin D metabolism and pathway | ||||
| Reactome | Vitamin D (calciferol) metabolism | ||||
| WikiPathways | Metapathway biotransformation | ||||
| Oxidation by Cytochrome P450 | |||||
| Nuclear Receptors in Lipid Metabolism and Toxicity | |||||
| Vitamin D Receptor Pathway | |||||
| Metabolism of steroid hormones and vitamin D | |||||
| Phase 1 - Functionalization of compounds | |||||
| Vitamin D Metabolism | |||||
| References | |||||
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