Target Information
| Target General Infomation | |||||
|---|---|---|---|---|---|
| Target ID |
T07466
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| Former ID |
TTDR00030
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| Target Name |
Glycosyltransferase MurG
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| Gene Name |
murG
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| Synonyms |
MurG; Undecaprenyl-PP-MurNAc-pentapeptide-UDPGlcNAc GlcNAc transferase; murG
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| Target Type |
Research
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| Function |
Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II).
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| BioChemical Class |
Hexosyltransferase
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| UniProt ID | |||||
| EC Number |
EC 2.4.1.227
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| Sequence |
MSGQGKRLMVMAGGTGGHVFPGLAVAHHLMAQGWQVRWLGTADRMEADLVPKHGIEIDFI
RISGLRGKGIKALIAAPLRIFNAWRQARAIMKAYKPDVVLGMGGYVSGPGGLAAWSLGIP VVLHEQNGIAGLTNKWLAKIATKVMQAFPGAFPNAEVVGNPVRTDVLALPLPQQRLAGRE GPVRVLVVGGSQGARILNQTMPQVAAKLGDSVTIWHQSGKGSQQSVEQAYAEAGQPQHKV TEFIDDMAAAYAWADVVVCRSGALTVSEIAAAGLPALFVPFQHKDRQQYWNALPLEKAGA AKIIEQPQLSVDAVANTLAGWSRETLLTMAERARAASIPDATERVANEVSRVARA |
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| Inhibitor | Uridine-Diphosphate-N-Acetylgalactosamine | Drug Info | [1] | ||
| Pathways | |||||
| PANTHER Pathway | Peptidoglycan biosynthesis | ||||
| References | |||||
| REF 1 | How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. | ||||
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