Target Information

Target General Infomation
Target ID
T15851
Former ID
TTDR00231
Target Name
Orotidine 5'-monophosphate decarboxylase
Gene Name
UMPS
Synonyms
OMP decarboxylase; OMPDCase; OMPdecase; Orotidine decarboxylase; UMPS
Target Type
Research
BioChemical Class
Pentosyltransferase
Target Validation
T15851
UniProt ID
P11172
EC Number
EC 4.1.1.23
Sequence
MAVARAALGPLVTGLYDVQAFKFGDFVLKSGLSSPIYIDLRGIVSRPRLLSQVADILFQT
AQNAGISFDTVCGVPYTALPLATVICSTNQIPMLIRRKETKDYGTKRLVEGTINPGETCL
IIEDVVTSGSSVLETVEVLQKEGLKVTDAIVLLDREQGGKDKLQAHGIRLHSVCTLSKML
EILEQQKKVDAETVGRVKRFIQENVFVAANHNGSPLSIKEAPKELSFGARAELPRIHPVA
SKLLRLMQKKETNLCLSADVSLARELLQLADALGPSICMLKTHVDILNDFTLDVMKELIT
LAKCHEFLIFEDRKFADIGNTVKKQYEGGIFKIASWADLVNAHVVPGSGVVKGLQEVGLP
LHRGCLLIAEMSSTGSLATGDYTRAAVRMAEEHSEFVVGFISGSRVSMKPEFLHLTPGVQ
LEAGGDNLGQQYNSPQEVIGKRGSDIIIVGRGIISAADRLEAAEMYRKAAWEAYLSRLGV
Structure
1ORO; 2EAW; 2JGY; 2P1F; 2QCC; 2QCD; 2QCE; 2QCF; 2QCG; 2QCH; 2QCL; 2QCM; 2QCN; 2V30; 2WNS; 3BGG; 3BGJ; 3BK0; 3BVJ; 3DBP; 3EWU; 3EWW; 3EWX; 3EWY; 3EWZ; 3EX1; 3EX2; 3EX3; 3EX4; 3EX6; 3G3D; 3G3M; 3L0K; 3L0N; 3MI2; 3MO7; 3MW7; 4HIB; 4HKP
Inhibitor 5-fluoro-6-amino-UMP Drug Info [529995]
5-fluoro-6-azido-UMP Drug Info [529995]
5-Fluoro-6-ethyluridine-5'-O-monophosphate Drug Info [529995]
5-fluoro-6-iodo-UMP Drug Info [529995]
6-Hydroxyuridine-5'-Phosphate Drug Info [551393]
Alpha-Phosphoribosylpyrophosphoric Acid Drug Info [551374]
Pyrazofurin Drug Info [537918]
Pathways
BioCyc Pathway Superpathway of pyrimidine deoxyribonucleotides de novo biosynthesis
Superpathway of pyrimidine ribonucleotides de novo biosynthesis
UMP biosynthesis
KEGG Pathway Pyrimidine metabolism
Drug metabolism - other enzymes
Metabolic pathways
NetPath Pathway TGF_beta_Receptor Signaling Pathway
Reactome Pyrimidine biosynthesis
WikiPathways Metabolism of nucleotides
Fluoropyrimidine Activity
References
Ref 529995J Med Chem. 2009 Mar 26;52(6):1648-58.Structure-activity relationships of orotidine-5'-monophosphate decarboxylase inhibitors as anticancer agents.
Ref 537918Molecular approaches for the treatment of hemorrhagic fever virus infections. Antiviral Res. 1993 Sep;22(1):45-75.
Ref 551374The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42.
Ref 551393How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6.

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