Target Information

Target General Infomation
Target ID
T17710
Former ID
TTDI02310
Target Name
Zonulin
Gene Name
HP
Synonyms
Haptoglobin; Haptoglobin beta chain; HP
Target Type
Clinical Trial
Disease Autoimmune diabetes [ICD10: E08-E13]
Function
Uncleaved haptoglogin, also known as zonulin, plays a role in intestinal permeability, allowing intercellular tight junction disassembly, and controlling the equilibrium between tolerance and immunity to non-self antigens. {ECO:0000269|PubMed:21248165}.
BioChemical Class
Peptidase
UniProt ID
P00738
Sequence
MSALGAVIALLLWGQLFAVDSGNDVTDIADDGCPKPPEIAHGYVEHSVRYQCKNYYKLRT
EGDGVYTLNDKKQWINKAVGDKLPECEADDGCPKPPEIAHGYVEHSVRYQCKNYYKLRTE
GDGVYTLNNEKQWINKAVGDKLPECEAVCGKPKNPANPVQRILGGHLDAKGSFPWQAKMV
SHHNLTTGATLINEQWLLTTAKNLFLNHSENATAKDIAPTLTLYVGKKQLVEIEKVVLHP
NYSQVDIGLIKLKQKVSVNERVMPICLPSKDYAEVGRVGYVSGWGRNANFKFTDHLKYVM
LPVADQDQCIRHYEGSTVPEKKTPKSPVGVQPILNEHTFCAGMSKYQEDTCYGDAGSAFA
VHDLEEDTWYATGILSFDKSCAVAEYGVYVKVTSIQDWVQKTIAEN
Drugs and Mode of Action
Drug(s) AT1001 Drug Info Phase 3 Autoimmune diabetes [522704]
Modulator AT1001 Drug Info
References
Ref 522704ClinicalTrials.gov (NCT00925301) Study of the Effects of Oral AT1001 (Migalastat Hydrochloride) in Patients With Fabry Disease. U.S. National Institutes of Health.

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