Target Information

Target General Infomation
Target ID
T25847
Former ID
TTDS00417
Target Name
Peptidyl-prolyl cis-trans isomerase B
Gene Name
PPIB
Synonyms
CYP-S1; CYPB; Cyclophilin B; PPIase; Rotamase; S-cyclophilin; SCYLP; PPIB
Target Type
Successful
Disease Dietary shortage [ICD9: 260-269; ICD10: E40-E46]
Function
PPIases accelerate the foldingof proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.
BioChemical Class
Cis-trans-isomerases
UniProt ID
P23284
EC Number
EC 5.2.1.8
Sequence
MLRLSERNMKVLLAAALIAGSVFFLLLPGPSAADEKKKGPKVTVKVYFDLRIGDEDVGRV
IFGLFGKTVPKTVDNFVALATGEKGFGYKNSKFHRVIKDFMIQGGDFTRGDGTGGKSIYG
ERFPDENFKLKHYGPGWVSMANAGKDTNGSQFFITTVKTAWLDGKHVVFGKVLEGMEVVR
KVESTKTDSRDKPLKDVIIADCGKIEVEKPFAIAKE
Drugs and Mode of Action
Drug(s) L-Proline Drug Info Approved Dietary shortage [536004], [540275]
Inhibitor 1,4-Dithiothreitol Drug Info [551393]
Binder L-Proline Drug Info [536004]
Pathways
Pathway Interaction Database Syndecan-1-mediated signaling events
PathWhiz Pathway Retinol Metabolism
Reactome Collagen biosynthesis and modifying enzymes
WikiPathways Collagen biosynthesis and modifying enzymes
miR-targeted genes in muscle cell - TarBase
miR-targeted genes in lymphocytes - TarBase
miR-targeted genes in leukocytes - TarBase
miR-targeted genes in epithelium - TarBase
References
Ref 536004Escherichia coli cyclophilin B binds a highly distorted form of trans-prolyl peptide isomer. Eur J Biochem. 2004 Sep;271(18):3794-803.
Ref 540275(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 3314).
Ref 536004Escherichia coli cyclophilin B binds a highly distorted form of trans-prolyl peptide isomer. Eur J Biochem. 2004 Sep;271(18):3794-803.
Ref 551393How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6.

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