Target Information
| Target General Infomation | |||||
|---|---|---|---|---|---|
| Target ID |
T25927
|
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| Former ID |
TTDR01396
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| Target Name |
mRNA of human caspase 6
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| Gene Name |
CASP6
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| Synonyms |
Apoptotic protease Mch2 (mRNA); CASP6 (mRNA); Caspase6 (mRNA); Caspase6 subunit p11 (mRNA); CASP6
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| Target Type |
Research
|
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| Function |
Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves poly(ADP-ribose) polymerase in vitro, as well as lamins. Overexpression promotes programmed cell death.
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| BioChemical Class |
Peptidase
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| Target Validation |
T25927
|
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| UniProt ID | |||||
| EC Number |
EC 3.4.22.59
|
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| Sequence |
MSSASGLRRGHPAGGEENMTETDAFYKREMFDPAEKYKMDHRRRGIALIFNHERFFWHLT
LPERRGTCADRDNLTRRFSDLGFEVKCFNDLKAEELLLKIHEVSTVSHADADCFVCVFLS HGEGNHIYAYDAKIEIQTLTGLFKGDKCHSLVGKPKIFIIQACRGNQHDVPVIPLDVVDN QTEKLDTNITEVDAASVYTLPAGADFLMCYSVAEGYYSHRETVNGSWYIQDLCEMLGKYG SSLEFTELLTLVNRKVSQRRVDFCKDPSAIGKKQVPCFASMLTKKLHFFPKSN |
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| Pathways | |||||
| KEGG Pathway | Apoptosis | ||||
| NetPath Pathway | TCR Signaling Pathway | ||||
| PANTHER Pathway | FAS signaling pathway | ||||
| Pathway Interaction Database | Direct p53 effectors | ||||
| p75(NTR)-mediated signaling | |||||
| C-MYB transcription factor network | |||||
| Negative effector of Fas and TNF-alpha | |||||
| Caspase Cascade in Apoptosis | |||||
| Reactome | Apoptotic cleavage of cellular proteins | ||||
| Caspase-mediated cleavage of cytoskeletal proteins | |||||
| WikiPathways | Apoptosis Modulation by HSP70 | ||||
| FAS pathway and Stress induction of HSP regulation | |||||
| Apoptosis | |||||
| Parkinsons Disease Pathway | |||||
| Apoptotic execution phase | |||||
| Apoptosis Modulation and Signaling | |||||
| References | |||||
| Ref 528057 | J Med Chem. 2006 Mar 9;49(5):1613-23.Design, synthesis, and biological evaluation of isoquinoline-1,3,4-trione derivatives as potent caspase-3 inhibitors. | ||||
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