Target Information
Target General Infomation | |||||
---|---|---|---|---|---|
Target ID |
T38996
|
||||
Former ID |
TTDR00374
|
||||
Target Name |
Phospholipase D1
|
||||
Gene Name |
PLD1
|
||||
Synonyms |
Choline phosphatase 1; HPLD1; PLD 1; Phosphatidylcholine-hydrolyzing phospholipase D1; PLD1
|
||||
Target Type |
Research
|
||||
Function |
Implicated as a critical step in numerous cellular pathways, including signal transduction, membrane trafficking, and the regulation of mitosis. May be involved in the regulation of perinuclear intravesicular membrane traffic (By similarity).
|
||||
BioChemical Class |
Phosphoric diester hydrolases
|
||||
Target Validation |
T38996
|
||||
UniProt ID | |||||
EC Number |
EC 3.1.4.4
|
||||
Sequence |
MSLKNEPRVNTSALQKIAADMSNIIENLDTRELHFEGEEVDYDVSPSDPKIQEVYIPFSA
IYNTQGFKEPNIQTYLSGCPIKAQVLEVERFTSTTRVPSINLYTIELTHGEFKWQVKRKF KHFQEFHRELLKYKAFIRIPIPTRRHTFRRQNVREEPREMPSLPRSSENMIREEQFLGRR KQLEDYLTKILKMPMYRNYHATTEFLDISQLSFIHDLGPKGIEGMIMKRSGGHRIPGLNC CGQGRACYRWSKRWLIVKDSFLLYMKPDSGAIAFVLLVDKEFKIKVGKKETETKYGIRID NLSRTLILKCNSYRHARWWGGAIEEFIQKHGTNFLKDHRFGSYAAIQENALAKWYVNAKG YFEDVANAMEEANEEIFITDWWLSPEIFLKRPVVEGNRWRLDCILKRKAQQGVRIFIMLY KEVELALGINSEYTKRTLMRLHPNIKVMRHPDHVSSTVYLWAHHEKLVIIDQSVAFVGGI DLAYGRWDDNEHRLTDVGSVKRVTSGPSLGSLPPAAMESMESLRLKDKNEPVQNLPIQKS IDDVDSKLKGIGKPRKFSKFSLYKQLHRHHLHDADSISSIDSTSSYFNHYRSHHNLIHGL KPHFKLFHPSSESEQGLTRPHADTGSIRSLQTGVGELHGETRFWHGKDYCNFVFKDWVQL DKPFADFIDRYSTPRMPWHDIASAVHGKAARDVARHFIQRWNFTKIMKSKYRSLSYPFLL PKSQTTAHELRYQVPGSVHANVQLLRSAADWSAGIKYHEESIHAAYVHVIENSRHYIYIE NQFFISCADDKVVFNKIGDAIAQRILKAHRENQKYRVYVVIPLLPGFEGDISTGGGNALQ AIMHFNYRTMCRGENSILGQLKAELGNQWINYISFCGLRTHAELEGNLVTELIYVHSKLL IADDNTVIIGSANINDRSMLGKRDSEMAVIVQDTETVPSVMDGKEYQAGRFARGLRLQCF RVVLGYLDDPSEDIQDPVSDKFFKEVWVSTAARNATIYDKVFRCLPNDEVHNLIQLRDFI NKPVLAKEDPIRAEEELKKIRGFLVQFPFYFLSEESLLPSVGTKEAIVPMEVWT |
||||
Target Expression Profile (TEP) and Drug Resistance Mutation (DRM) | |||||
TEP | EXP Info | ||||
Pathways | |||||
BioCyc Pathway | Phospholipases | ||||
KEGG Pathway | Glycerophospholipid metabolism | ||||
Ether lipid metabolism | |||||
Metabolic pathways | |||||
Ras signaling pathway | |||||
cAMP signaling pathway | |||||
Sphingolipid signaling pathway | |||||
Endocytosis | |||||
Fc gamma R-mediated phagocytosis | |||||
Glutamatergic synapse | |||||
GnRH signaling pathway | |||||
Pathways in cancer | |||||
Pancreatic cancer | |||||
Choline metabolism in cancer | |||||
PANTHER Pathway | Angiogenesis | ||||
Ras Pathway | |||||
Pathway Interaction Database | RhoA signaling pathway | ||||
Arf6 trafficking events | |||||
CDC42 signaling events | |||||
Arf6 downstream pathway | |||||
mTOR signaling pathway | |||||
ErbB1 downstream signaling | |||||
IL8- and CXCR1-mediated signaling events | |||||
Alpha-synuclein signaling | |||||
Reactome | Role of phospholipids in phagocytosis | ||||
WikiPathways | EGF/EGFR Signaling Pathway | ||||
TSH signaling pathway | |||||
References |
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.