Target General Infomation
Target ID
T38996
Former ID
TTDR00374
Target Name
Phospholipase D1
Gene Name
PLD1
Synonyms
Choline phosphatase 1; HPLD1; PLD 1; Phosphatidylcholine-hydrolyzing phospholipase D1; PLD1
Target Type
Research
Function
Implicated as a critical step in numerous cellular pathways, including signal transduction, membrane trafficking, and the regulation of mitosis. May be involved in the regulation of perinuclear intravesicular membrane traffic (By similarity).
BioChemical Class
Phosphoric diester hydrolases
Target Validation
T38996
UniProt ID
EC Number
EC 3.1.4.4
Sequence
MSLKNEPRVNTSALQKIAADMSNIIENLDTRELHFEGEEVDYDVSPSDPKIQEVYIPFSA
IYNTQGFKEPNIQTYLSGCPIKAQVLEVERFTSTTRVPSINLYTIELTHGEFKWQVKRKF
KHFQEFHRELLKYKAFIRIPIPTRRHTFRRQNVREEPREMPSLPRSSENMIREEQFLGRR
KQLEDYLTKILKMPMYRNYHATTEFLDISQLSFIHDLGPKGIEGMIMKRSGGHRIPGLNC
CGQGRACYRWSKRWLIVKDSFLLYMKPDSGAIAFVLLVDKEFKIKVGKKETETKYGIRID
NLSRTLILKCNSYRHARWWGGAIEEFIQKHGTNFLKDHRFGSYAAIQENALAKWYVNAKG
YFEDVANAMEEANEEIFITDWWLSPEIFLKRPVVEGNRWRLDCILKRKAQQGVRIFIMLY
KEVELALGINSEYTKRTLMRLHPNIKVMRHPDHVSSTVYLWAHHEKLVIIDQSVAFVGGI
DLAYGRWDDNEHRLTDVGSVKRVTSGPSLGSLPPAAMESMESLRLKDKNEPVQNLPIQKS
IDDVDSKLKGIGKPRKFSKFSLYKQLHRHHLHDADSISSIDSTSSYFNHYRSHHNLIHGL
KPHFKLFHPSSESEQGLTRPHADTGSIRSLQTGVGELHGETRFWHGKDYCNFVFKDWVQL
DKPFADFIDRYSTPRMPWHDIASAVHGKAARDVARHFIQRWNFTKIMKSKYRSLSYPFLL
PKSQTTAHELRYQVPGSVHANVQLLRSAADWSAGIKYHEESIHAAYVHVIENSRHYIYIE
NQFFISCADDKVVFNKIGDAIAQRILKAHRENQKYRVYVVIPLLPGFEGDISTGGGNALQ
AIMHFNYRTMCRGENSILGQLKAELGNQWINYISFCGLRTHAELEGNLVTELIYVHSKLL
IADDNTVIIGSANINDRSMLGKRDSEMAVIVQDTETVPSVMDGKEYQAGRFARGLRLQCF
RVVLGYLDDPSEDIQDPVSDKFFKEVWVSTAARNATIYDKVFRCLPNDEVHNLIQLRDFI
NKPVLAKEDPIRAEEELKKIRGFLVQFPFYFLSEESLLPSVGTKEAIVPMEVWT
Inhibitor 1-(pyridin-2-yl)piperazine Drug Info [530029]
1-(pyridin-4-yl)piperazine Drug Info [530029]
HALOPEMIDE Drug Info [529914]
Target Expression Profile (TEP) and Drug Resistance Mutation (DRM)
TEP EXP Info
Pathways
BioCyc Pathway Phospholipases
KEGG Pathway Glycerophospholipid metabolism
Ether lipid metabolism
Metabolic pathways
Ras signaling pathway
cAMP signaling pathway
Sphingolipid signaling pathway
Endocytosis
Fc gamma R-mediated phagocytosis
Glutamatergic synapse
GnRH signaling pathway
Pathways in cancer
Pancreatic cancer
Choline metabolism in cancer
PANTHER Pathway Angiogenesis
Ras Pathway
Pathway Interaction Database RhoA signaling pathway
Arf6 trafficking events
CDC42 signaling events
Arf6 downstream pathway
mTOR signaling pathway
ErbB1 downstream signaling
IL8- and CXCR1-mediated signaling events
Alpha-synuclein signaling
Reactome Role of phospholipids in phagocytosis
WikiPathways EGF/EGFR Signaling Pathway
TSH signaling pathway
References
Ref 529914Nat Chem Biol. 2009 Feb;5(2):108-17. Epub 2009 Jan 11.Design of isoform-selective phospholipase D inhibitors that modulate cancer cell invasiveness.
Ref 530029Bioorg Med Chem Lett. 2009 Apr 15;19(8):2240-3. Epub 2009 Mar 6.Design and synthesis of isoform-selective phospholipase D (PLD) inhibitors. Part II. Identification of the 1,3,8-triazaspiro[4,5]decan-4-one privileged structure that engenders PLD2 selectivity.

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