Target Information

Target General Infomation
Target ID
T41750
Former ID
TTDI02342
Target Name
Gastric inhibitory polypeptide receptor
Gene Name
GIPR
Synonyms
Glucosedependent insulinotropic polypeptide receptor; GIPR
Target Type
Discontinued
Disease Type 2 diabetes [ICD9: 250; ICD10: E11]
Function
This is a receptor for GIP. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.
BioChemical Class
GPCR secretin
UniProt ID
P48546
Sequence
MTTSPILQLLLRLSLCGLLLQRAETGSKGQTAGELYQRWERYRRECQETLAAAEPPSGLA
CNGSFDMYVCWDYAAPNATARASCPWYLPWHHHVAAGFVLRQCGSDGQWGLWRDHTQCEN
PEKNEAFLDQRLILERLQVMYTVGYSLSLATLLLALLILSLFRRLHCTRNYIHINLFTSF
MLRAAAILSRDRLLPRPGPYLGDQALALWNQALAACRTAQIVTQYCVGANYTWLLVEGVY
LHSLLVLVGGSEEGHFRYYLLLGWGAPALFVIPWVIVRYLYENTQCWERNEVKAIWWIIR
TPILMTILINFLIFIRILGILLSKLRTRQMRCRDYRLRLARSTLTLVPLLGVHEVVFAPV
TEEQARGALRFAKLGFEIFLSSFQGFLVSVLYCFINKEVQSEIRRGWHHCRLRRSLGEEQ
RQLPERAFRALPSGSGPGEVPTSRGLSSGTLPGPGNEASRELESYC
Drugs and Mode of Action
Drug(s) RG7685 Drug Info Discontinued in Phase 2 Type 2 diabetes [549037]
RG7697 Drug Info Discontinued in Phase 2 Type 2 diabetes [549262]
Modulator RG7685 Drug Info
RG7697 Drug Info
Target Expression Profile (TEP) and Drug Resistance Mutation (DRM)
TEP EXP Info
Pathways
KEGG Pathway cAMP signaling pathway
Neuroactive ligand-receptor interaction
Reactome G alpha (s) signalling events
Glucagon-type ligand receptors
WikiPathways GPCRs, Class B Secretin-like
GPCR ligand binding
GPCR downstream signaling
References
Ref 549037Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800031660)
Ref 549262Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800034341)

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