Target Information
Target General Infomation | |||||
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Target ID |
T48703
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Former ID |
TTDC00056
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Target Name |
Toll-like receptor 8
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Gene Name |
TLR8
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Synonyms |
CD288 antigen; TLR8
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Target Type |
Clinical Trial
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Disease | Autoimmune diabetes [ICD10: E08-E13] | ||||
Allergic rhinitis [ICD9: 472.0, 477, 995.3; ICD10: J00, J30, J31.0, T78.4] | |||||
Allergy [ICD9: 995.3; ICD10: T78.4] | |||||
Diffuse large B-cell lymphoma [ICD9: 200; ICD10: C83.3] | |||||
Herpes simplex virus infection [ICD9: 54; ICD10: B00] | |||||
Systemic lupus erythematosus [ICD9: 710; ICD10: M32] | |||||
Function |
Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response.
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BioChemical Class |
Toll-like receptor family
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Target Validation |
T48703
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UniProt ID | |||||
Sequence |
MENMFLQSSMLTCIFLLISGSCELCAEENFSRSYPCDEKKQNDSVIAECSNRRLQEVPQT
VGKYVTELDLSDNFITHITNESFQGLQNLTKINLNHNPNVQHQNGNPGIQSNGLNITDGA FLNLKNLRELLLEDNQLPQIPSGLPESLTELSLIQNNIYNITKEGISRLINLKNLYLAWN CYFNKVCEKTNIEDGVFETLTNLELLSLSFNSLSHVPPKLPSSLRKLFLSNTQIKYISEE DFKGLINLTLLDLSGNCPRCFNAPFPCVPCDGGASINIDRFAFQNLTQLRYLNLSSTSLR KINAAWFKNMPHLKVLDLEFNYLVGEIASGAFLTMLPRLEILDLSFNYIKGSYPQHINIS RNFSKLLSLRALHLRGYVFQELREDDFQPLMQLPNLSTINLGINFIKQIDFKLFQNFSNL EIIYLSENRISPLVKDTRQSYANSSSFQRHIRKRRSTDFEFDPHSNFYHFTRPLIKPQCA AYGKALDLSLNSIFFIGPNQFENLPDIACLNLSANSNAQVLSGTEFSAIPHVKYLDLTNN RLDFDNASALTELSDLEVLDLSYNSHYFRIAGVTHHLEFIQNFTNLKVLNLSHNNIYTLT DKYNLESKSLVELVFSGNRLDILWNDDDNRYISIFKGLKNLTRLDLSLNRLKHIPNEAFL NLPASLTELHINDNMLKFFNWTLLQQFPRLELLDLRGNKLLFLTDSLSDFTSSLRTLLLS HNRISHLPSGFLSEVSSLKHLDLSSNLLKTINKSALETKTTTKLSMLELHGNPFECTCDI GDFRRWMDEHLNVKIPRLVDVICASPGDQRGKSIVSLELTTCVSDVTAVILFFFTFFITT MVMLAALAHHLFYWDVWFIYNVCLAKVKGYRSLSTSQTFYDAYISYDTKDASVTDWVINE LRYHLEESRDKNVLLCLEERDWDPGLAIIDNLMQSINQSKKTVFVLTKKYAKSWNFKTAF YLALQRLMDENMDVIIFILLEPVLQHSQYLRLRQRICKSSILQWPDNPKAEGLFWQTLRN VVLTENDSRYNNMYVDSIKQY |
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Drugs and Mode of Action | |||||
Drug(s) | Resiquimod | Drug Info | Phase 1/2 | Herpes simplex virus infection | [468141], [546884] |
CPG 52364 | Drug Info | Phase 1 | Systemic lupus erythematosus | [532501] | |
VTX-1463 | Drug Info | Phase 1 | Allergic rhinitis | [548896] | |
VTX-2337 | Drug Info | Discontinued in Phase 2 | Allergy | [524026] | |
IM0-8400 | Drug Info | Discontinued in Phase 1/2 | Diffuse large B-cell lymphoma | [550999] | |
Pathways | |||||
KEGG Pathway | Toll-like receptor signaling pathway | ||||
NetPath Pathway | Leptin Signaling Pathway | ||||
TCR Signaling Pathway | |||||
PANTHER Pathway | Toll receptor signaling pathway | ||||
Reactome | Trafficking and processing of endosomal TLR | ||||
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling | |||||
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | |||||
MyD88 dependent cascade initiated on endosome | |||||
WikiPathways | Toll-like receptor signaling pathway | ||||
Toll-Like Receptors Cascades | |||||
MyD88 dependent cascade initiated on endosome | |||||
Trafficking and processing of endosomal TLR | |||||
Regulation of toll-like receptor signaling pathway | |||||
References | |||||
Ref 468141 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5051). | ||||
Ref 524026 | ClinicalTrials.gov (NCT01666444) VTX-2337 and Pegylated Liposomal Doxorubicin (PLD) in Patients With Recurrent or Persistent Epithelial Ovarian, Fallopian Tube or Primary Peritoneal Cancer. U.S. National Institutes of Health. | ||||
Ref 532501 | Treatment of systemic lupus erythematosus: new therapeutic avenues and blind alleys. Nat Rev Rheumatol. 2014 Jan;10(1):23-34. | ||||
Ref 546884 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800010858) | ||||
Ref 531464 | VTX-1463, a novel TLR8 agonist for the treatment of allergic rhinitis. Expert Opin Investig Drugs. 2011 Jul;20(7):981-6. | ||||
Ref 543476 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1758). |
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