Target Information
| Target General Infomation | |||||
|---|---|---|---|---|---|
| Target ID |
T49064
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| Former ID |
TTDS00429
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| Target Name |
Gastric triacylglycerol lipase
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| Gene Name |
LIPF
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| Synonyms |
GL; Gastric lipase; LIPF
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| Target Type |
Clinical Trial
|
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| Disease | Diabetes; Obesity [ICD9: 250, 278; ICD10: E08-E13, E66] | ||||
| BioChemical Class |
Carboxylic ester hydrolase
|
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| UniProt ID | |||||
| EC Number |
EC 3.1.1.3
|
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| Sequence |
MWLLLTMASLISVLGTTHGLFGKLHPGSPEVTMNISQMITYWGYPNEEYEVVTEDGYILE
VNRIPYGKKNSGNTGQRPVVFLQHGLLASATNWISNLPNNSLAFILADAGYDVWLGNSRG NTWARRNLYYSPDSVEFWAFSFDEMAKYDLPATIDFIVKKTGQKQLHYVGHSQGTTIGFI AFSTNPSLAKRIKTFYALAPVATVKYTKSLINKLRFVPQSLFKFIFGDKIFYPHNFFDQF LATEVCSREMLNLLCSNALFIICGFDSKNFNTSRLDVYLSHNPAGTSVQNMFHWTQAVKS GKFQAYDWGSPVQNRMHYDQSQPPYYNVTAMNVPIAVWNGGKDLLADPQDVGLLLPKLPN LIYHKEIPFYNHLDFIWAMDAPQEVYNDIVSMISEDKK |
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| Structure |
1HLG
|
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| Drugs and Mode of Action | |||||
| Drug(s) | Cetilistat | Drug Info | Phase 3 | Diabetes; Obesity | [1], [2] |
| Inhibitor | B-Octylglucoside | Drug Info | [3] | ||
| Undecyl-Phosphinic Acid Butyl Ester | Drug Info | [4] | |||
| Modulator | Cetilistat | Drug Info | [1] | ||
| Pathways | |||||
| BioCyc Pathway | Triacylglycerol degradation | ||||
| KEGG Pathway | Glycerolipid metabolism | ||||
| Metabolic pathways | |||||
| Fat digestion and absorption | |||||
| NetPath Pathway | EGFR1 Signaling Pathway | ||||
| WikiPathways | Triacylglyceride Synthesis | ||||
| Fatty Acid Beta Oxidation | |||||
| References | |||||
| REF 1 | Cetilistat (ATL-962), a novel lipase inhibitor: a 12-week randomized, placebo-controlled study of weight reduction in obese patients. Int J Obes (Lond). 2007 Mar;31(3):494-9. Epub 2006 Sep 5. | ||||
| REF 2 | Anti-obesity drugs. Expert Opin Pharmacother. 2008 Jun;9(8):1339-50. | ||||
| REF 3 | How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. | ||||
| REF 4 | The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. | ||||
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