Target Information

Target General Infomation
Target ID
T51843
Former ID
TTDC00001
Target Name
RNA-dependentRNA polymerase
Synonyms
NI-b; NIb; NS5B; Nonstructuralprotein 5b; Nuclear inclusion protein B; P66; P70; RNA-directed RNA polymerase; RdRp; Virus-encodednonstructural protein 5B
Target Type
Discontinued
Disease Viral infections [ICD9: 054.0, 054.1, 054.2, 054.3, 075, 771.2, 052, 053; ICD10: B01, B02, A60, B00, B27, G05.1, P35.2]
BioChemical Class
Kinase
Target Validation
T51843
EC Number
EC 2.7.7.48
Drugs and Mode of Action
Drug(s) Flutimide Drug Info Terminated Discovery agent [546072]
Inhibitor FdG Drug Info [536317], [536620], [536903]
Flutimide Drug Info [536317], [536620], [536903]
Guanosine-5'-Triphosphate Drug Info [551393]
Pyrimidinyl acylthiourea Drug Info [536317], [536620], [536903]
Pyrophosphate 2- Drug Info [551374]
T-1105 Drug Info [536317], [536620], [536903]
T-1106 Drug Info [536317], [536620], [536903]
Thiadiazolo[2,3-a]pyrimidine Drug Info [536317], [536620], [536903]
References
Ref 546072Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800006184)
Ref 536317Antiviral agents active against influenza A viruses. Nat Rev Drug Discov. 2006 Dec;5(12):1015-25.
Ref 536620PA subunit of RNA polymerase as a promising target for anti-influenza virus agents. Antiviral Res. 2008 Jun;78(3):194-201. Epub 2008 Jan 17.
Ref 536903Activity of T-705 in a hamster model of yellow fever virus infection in comparison with that of a chemically related compound, T-1106. Antimicrob Agents Chemother. 2009 Jan;53(1):202-9. Epub 2008 Oct 27.
Ref 551374The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42.
Ref 551393How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6.

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