Target Information

Target General Infomation
Target ID
T58298
Former ID
TTDR00537
Target Name
Ectonucleoside triphosphate diphosphohydrolase 1
Gene Name
ENTPD1
Synonyms
ATPDase; CD39 antigen; Ecto-ATP diphosphohydrolase; Ecto-apyrase; Ecto-nucleotidase CD-39; Lymphoid cell activation antigen; NTPDase1; ENTPD1
Target Type
Research
Function
In the nervous system, could hydrolyze atp and other nucleotides to regulate purinergic neurotransmission. Could also be implicated in the prevention of platelet aggregation. Hydrolyzes atp and adp equally well.
BioChemical Class
Acid anhydrides hydrolase
Target Validation
T58298
UniProt ID
P49961
EC Number
EC 3.6.1.5
Sequence
MEDTKESNVKTFCSKNILAILGFSSIIAVIALLAVGLTQNKALPENVKYGIVLDAGSSHT
SLYIYKWPAEKENDTGVVHQVEECRVKGPGISKFVQKVNEIGIYLTDCMERAREVIPRSQ
HQETPVYLGATAGMRLLRMESEELADRVLDVVERSLSNYPFDFQGARIITGQEEGAYGWI
TINYLLGKFSQKTRWFSIVPYETNNQETFGALDLGGASTQVTFVPQNQTIESPDNALQFR
LYGKDYNVYTHSFLCYGKDQALWQKLAKDIQVASNEILRDPCFHPGYKKVVNVSDLYKTP
CTKRFEMTLPFQQFEIQGIGNYQQCHQSILELFNTSYCPYSQCAFNGIFLPPLQGDFGAF
SAFYFVMKFLNLTSEKVSQEKVTEMMKKFCAQPWEEIKTSYAGVKEKYLSEYCFSGTYIL
SLLLQGYHFTADSWEHIHFIGKIQGSDAGWTLGYMLNLTNMIPAEQPLSTPLSHSTYVFL
MVLFSLVLFTVAIIGLLIFHKPSYFWKDMV
Inhibitor PSB-0963 Drug Info [530711]
PSB-6426 Drug Info [529598]
Pathways
BioCyc Pathway UTP and CTP dephosphorylation II
KEGG Pathway Purine metabolism
Pyrimidine metabolism
Epstein-Barr virus infection
References
Ref 529598J Med Chem. 2008 Aug 14;51(15):4518-28. Epub 2008 Jul 17.Selective nucleoside triphosphate diphosphohydrolase-2 (NTPDase2) inhibitors: nucleotide mimetics derived from uridine-5'-carboxamide.
Ref 530711J Med Chem. 2010 Mar 11;53(5):2076-86.Development of potent and selective inhibitors of ecto-5'-nucleotidase based on an anthraquinone scaffold.

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