Target Information
| Target General Infomation | |||||
|---|---|---|---|---|---|
| Target ID |
T59230
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| Former ID |
TTDR00811
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| Target Name |
Estradiol 17 beta-dehydrogenase 4
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| Gene Name |
HSD17B4
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| Synonyms |
17 beta-hydroxysteroid dehydrogenase type 4; 17-beta-HSD 4; 17-beta-hydroxysteroid dehydrogenase 4; D-bifunctional protein; DBP; MFE-2; HSD17B4
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| Target Type |
Research
|
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| Function |
Bifunctional enzymeacting on the peroxisomal beta- oxidation pathway for fatty acids. Catalyzes the formation of 3- ketoacyl-CoA intermediates from both straight-chain and 2-methyl- branched-chain fatty acids.
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| BioChemical Class |
Short-chain dehydrogenases reductases
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| UniProt ID | |||||
| EC Number |
EC 4.2.1.119
|
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| Sequence |
MGSPLRFDGRVVLVTGAGAGLGRAYALAFAERGALVVVNDLGGDFKGVGKGSLAADKVVE
EIRRRGGKAVANYDSVEEGEKVVKTALDAFGRIDVVVNNAGILRDRSFARISDEDWDIIH RVHLRGSFQVTRAAWEHMKKQKYGRIIMTSSASGIYGNFGQANYSAAKLGLLGLANSLAI EGRKSNIHCNTIAPNAGSRMTQTVMPEDLVEALKPEYVAPLVLWLCHESCEENGGLFEVG AGWIGKLRWERTLGAIVRQKNHPMTPEAVKANWKKICDFENASKPQSIQESTGSIIEVLS KIDSEGGVSANHTSRATSTATSGFAGAIGQKLPPFSYAYTELEAIMYALGVGASIKDPKD LKFIYEGSSDFSCLPTFGVIIGQKSMMGGGLAEIPGLSINFAKVLHGEQYLELYKPLPRA GKLKCEAVVADVLDKGSGVVIIMDVYSYSEKELICHNQFSLFLVGSGGFGGKRTSDKVKV AVAIPNRPPDAVLTDTTSLNQAALYRLSGDWNPLHIDPNFASLAGFDKPILHGLCTFGFS ARRVLQQFADNDVSRFKAIKARFAKPVYPGQTLQTEMWKEGNRIHFQTKVQETGDIVISN AYVDLAPTSGTSAKTPSEGGKLQSTFVFEEIGRRLKDIGPEVVKKVNAVFEWHITKGGNI GAKWTIDLKSGSGKVYQGPAKGAADTTIILSDEDFMEVVLGKLDPQKAFFSGRLKARGNI MLSQKLQMILKDYAKL |
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| Inhibitor | 3r-Hydroxydecanoyl-Coa | Drug Info | [1] | ||
| Nicotinamide-Adenine-Dinucleotide | Drug Info | [2] | |||
| Pathways | |||||
| BioCyc Pathway | Fatty acid beta-oxidation (peroxisome) | ||||
| KEGG Pathway | Primary bile acid biosynthesis | ||||
| Metabolic pathways | |||||
| Peroxisome | |||||
| PathWhiz Pathway | Bile Acid Biosynthesis | ||||
| WikiPathways | Steroid Biosynthesis | ||||
| alpha-linolenic (omega3) and linoleic (omega6) acid metabolism | |||||
| Prostate Cancer | |||||
| Peroxisomal beta-oxidation of tetracosanoyl-CoA | |||||
| Peroxisomal lipid metabolism | |||||
| Bile acid and bile salt metabolism | |||||
| References | |||||
| REF 1 | DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Nucleic Acids Res. 2011 Jan;39(Database issue):D1035-4. Nucleic Acids Res. 2011 January | ||||
| REF 2 | How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. | ||||
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