Target Information

Target General Infomation
Target ID
T62265
Former ID
TTDR00848
Target Name
Deoxyhypusine synthase
Gene Name
DHPS
Synonyms
DHS; DHPS
Target Type
Research
Function
Catalyzes the NAD-dependent oxidativecleavage of spermidine and the subsequent transfer of the butylamine moiety of spermidine to the epsilon-amino group of a specific lysine residue of the eIF-5A precursor protein to form the intermediate deoxyhypusine residue.
BioChemical Class
Alkyl aryl transferase
Target Validation
T62265
UniProt ID
P49366
EC Number
EC 2.5.1.46
Sequence
MEGSLEREAPAGALAAVLKHSSTLPPESTQVRGYDFNRGVNYRALLEAFGTTGFQATNFG
RAVQQVNAMIEKKLEPLSQDEDQHADLTQSRRPLTSCTIFLGYTSNLISSGIRETIRYLV
QHNMVDVLVTTAGGVEEDLIKCLAPTYLGEFSLRGKELRENGINRIGNLLVPNENYCKFE
DWLMPILDQMVMEQNTEGVKWTPSKMIARLGKEINNPESVYYWAQKNHIPVFSPALTDGS
LGDMIFFHSYKNPGLVLDIVEDLRLINTQAIFAKCTGMIILGGGVVKHHIANANLMRNGA
DYAVYINTAQEFDGSDSGARPDEAVSWGKIRVDAQPVKVYADASLVFPLLVAETFAQKMD
AFMHEKNED
Inhibitor 1-Guanidinium-7-Aminoheptane Drug Info [551393]
GC7 Drug Info [538040]
N-guanyl-1,7-diaminoheptane Drug Info [528923]
N1-guanyl-1,7-diaminoheptane Drug Info [538040]
Nicotinamide-Adenine-Dinucleotide Drug Info [551393]
Pathways
BioCyc Pathway Hypusine biosynthesis
NetPath Pathway TGF_beta_Receptor Signaling Pathway
WikiPathways gamma carboxylation, hypusine formation and arylsulfatase activation
References
Ref 528923Bioorg Med Chem. 2007 Sep 15;15(18):6200-7. Epub 2007 Jun 14.Modification of eukaryotic initiation factor 5A from Plasmodium vivax by a truncated deoxyhypusine synthase from Plasmodium falciparum: An enzyme with dual enzymatic properties.
Ref 538040Effects of N1-guanyl-1,7-diaminoheptane, an inhibitor of deoxyhypusine synthase, on the growth of tumorigenic cell lines in culture. Biochim Biophys Acta. 1996 Jan 10;1310(1):119-26.
Ref 551393How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6.

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