Target Information
| Target General Infomation | |||||
|---|---|---|---|---|---|
| Target ID |
T62265
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| Former ID |
TTDR00848
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| Target Name |
Deoxyhypusine synthase
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| Gene Name |
DHPS
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| Synonyms |
DHS; DHPS
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| Target Type |
Research
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| Function |
Catalyzes the NAD-dependent oxidativecleavage of spermidine and the subsequent transfer of the butylamine moiety of spermidine to the epsilon-amino group of a specific lysine residue of the eIF-5A precursor protein to form the intermediate deoxyhypusine residue.
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| BioChemical Class |
Alkyl aryl transferase
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| Target Validation |
T62265
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| UniProt ID | |||||
| EC Number |
EC 2.5.1.46
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| Sequence |
MEGSLEREAPAGALAAVLKHSSTLPPESTQVRGYDFNRGVNYRALLEAFGTTGFQATNFG
RAVQQVNAMIEKKLEPLSQDEDQHADLTQSRRPLTSCTIFLGYTSNLISSGIRETIRYLV QHNMVDVLVTTAGGVEEDLIKCLAPTYLGEFSLRGKELRENGINRIGNLLVPNENYCKFE DWLMPILDQMVMEQNTEGVKWTPSKMIARLGKEINNPESVYYWAQKNHIPVFSPALTDGS LGDMIFFHSYKNPGLVLDIVEDLRLINTQAIFAKCTGMIILGGGVVKHHIANANLMRNGA DYAVYINTAQEFDGSDSGARPDEAVSWGKIRVDAQPVKVYADASLVFPLLVAETFAQKMD AFMHEKNED |
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| Inhibitor | 1-Guanidinium-7-Aminoheptane | Drug Info | [1] | ||
| GC7 | Drug Info | [2] | |||
| N-guanyl-1,7-diaminoheptane | Drug Info | [3] | |||
| N1-guanyl-1,7-diaminoheptane | Drug Info | [2] | |||
| Nicotinamide-Adenine-Dinucleotide | Drug Info | [1] | |||
| Pathways | |||||
| BioCyc Pathway | Hypusine biosynthesis | ||||
| NetPath Pathway | TGF_beta_Receptor Signaling Pathway | ||||
| WikiPathways | gamma carboxylation, hypusine formation and arylsulfatase activation | ||||
| References | |||||
| REF 1 | How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. | ||||
| REF 2 | Effects of N1-guanyl-1,7-diaminoheptane, an inhibitor of deoxyhypusine synthase, on the growth of tumorigenic cell lines in culture. Biochim Biophys Acta. 1996 Jan 10;1310(1):119-26. | ||||
| REF 3 | Bioorg Med Chem. 2007 Sep 15;15(18):6200-7. Epub 2007 Jun 14.Modification of eukaryotic initiation factor 5A from Plasmodium vivax by a truncated deoxyhypusine synthase from Plasmodium falciparum: An enzyme with dual enzymatic properties. | ||||
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