Target General Infomation
Target ID
T63083
Former ID
TTDR00922
Target Name
DNA repair protein RAD51 homolog 1
Gene Name
RAD51
Synonyms
HRAD51; HsRAD51; RAD51
Target Type
Research
Function
Participates in a common DNA damage response pathway associated with the activation of homologous recombination and double-strand break repair. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Underwinds duplex DNA and forms helical nucleoprotein filaments. Part of a PALB2- scaffolded HR complex containing BRCA2 and RAD51C and which is thought to play a role inDNA repair by HR. Plays a role in regulating mitochondrial DNA copy number under conditions of oxidative stress in the presence of RAD51C and XRCC3.
BioChemical Class
DNA repair
UniProt ID
Sequence
MAMQMQLEANADTSVEEESFGPQPISRLEQCGINANDVKKLEEAGFHTVEAVAYAPKKEL
INIKGISEAKADKILAEAAKLVPMGFTTATEFHQRRSEIIQITTGSKELDKLLQGGIETG
SITEMFGEFRTGKTQICHTLAVTCQLPIDRGGGEGKAMYIDTEGTFRPERLLAVAERYGL
SGSDVLDNVAYARAFNTDHQTQLLYQASAMMVESRYALLIVDSATALYRTDYSGRGELSA
RQMHLARFLRMLLRLADEFGVAVVITNQVVAQVDGAAMFAADPKKPIGGNIIAHASTTRL
YLRKGRGETRICKIYDSPCLPEAEAMFAINADGVGDAKD
Inhibitor Phosphoaminophosphonic Acid-Adenylate Ester Drug Info [551374]
Pathways
KEGG Pathway Homologous recombination
Fanconi anemia pathway
Pathways in cancer
Pancreatic cancer
Pathway Interaction Database p73 transcription factor network
ATR signaling pathway
BARD1 signaling events
Reactome HDR through Single Strand Annealing (SSA)
HDR through Homologous Recombination (HRR)
Presynaptic phase of homologous DNA pairing and strand exchange
Meiotic recombination
WikiPathways DNA Damage Response
Meiotic Recombination
ATM Signaling Pathway
Integrated Pancreatic Cancer Pathway
Integrated Breast Cancer Pathway
Homologous recombination
Double-Strand Break Repair
miRNA Regulation of DNA Damage Response
References
Ref 551374The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42.

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