Target Information

Target General Infomation
Target ID
T71905
Former ID
TTDS00216
Target Name
16S rRNA
Synonyms
Plastid 16S rRNA; RrnS
Target Type
Successful
Disease Bacterial infections [ICD9: 001-009, 010-018, 020-027, 030-041, 080-088, 090-099, 100-104; ICD10: A00-B99]
Gram-positive bacterial infection [ICD9: 001-009, 010-018, 020-027, 030-041, 080-088, 090-099, 100-104]
Target Validation
T71905
Drugs and Mode of Action
Drug(s) Framycetin Drug Info Approved Bacterial infections [550693]
Tetracyclines Drug Info Approved Bacterial infections [536854]
Oxazolidinones Drug Info Phase 2 Gram-positive bacterial infection [522273]
Inhibitor Aminodeoxykanamycin Drug Info [535081]
Apramycin Drug Info [535081]
Butirosin B Drug Info [535081]
Geneticin Drug Info [535081]
Hygromycin B Drug Info [535081]
Neamine Drug Info [535081]
Oxazolidinones Drug Info [534883]
Ribostamycin Drug Info [535081]
Binder Framycetin Drug Info [535064]
Tetracyclines Drug Info [536854]
References
Ref 522273ClinicalTrials.gov (NCT00646958) Safety and Efficacy Study of Oxazolidinones to Treat Uncomplicated Skin Infections. U.S. National Institutes of Health.
Ref 536854Has nature already identified all useful antibacterial targets? Curr Opin Microbiol. 2008 Oct;11(5):387-92. Epub 2008 Oct 6.
Ref 550693Drug information of Framycetin, 2008. eduDrugs.
Ref 534883Ribosomal RNA is the target for oxazolidinones, a novel class of translational inhibitors. RNA. 1999 Jul;5(7):939-46.
Ref 535064Antistaphylococcal activity of gentamicin. Minerva Med. 1975 Dec 8;66(84):4505-26.
Ref 535081RNA as a target for small molecules. Curr Opin Chem Biol. 2000 Dec;4(6):678-86.
Ref 536854Has nature already identified all useful antibacterial targets? Curr Opin Microbiol. 2008 Oct;11(5):387-92. Epub 2008 Oct 6.

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