Target Information
| Target General Infomation | |||||
|---|---|---|---|---|---|
| Target ID |
T72779
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| Former ID |
TTDR00983
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| Target Name |
Maspin
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| Gene Name |
SERPINB5
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| Synonyms |
Protease inhibitor 5; SERPINB5
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| Target Type |
Research
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| Function |
Tumor suppressor. It blocks the growth, invasion, and metastatic properties of mammary tumors. As it does not undergo the S (stressed) to R (relaxed) conformational transition characteristic of active serpins, it exhibits no serine protease inhibitory activity.
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| BioChemical Class |
Serpin family
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| UniProt ID | |||||
| Sequence |
MDALQLANSAFAVDLFKQLCEKEPLGNVLFSPICLSTSLSLAQVGAKGDTANEIGQVLHF
ENVKDVPFGFQTVTSDVNKLSSFYSLKLIKRLYVDKSLNLSTEFISSTKRPYAKELETVD FKDKLEETKGQINNSIKDLTDGHFENILADNSVNDQTKILVVNAAYFVGKWMKKFSESET KECPFRVNKTDTKPVQMMNMEATFCMGNIDSINCKIIELPFQNKHLSMFILLPKDVEDES TGLEKIEKQLNSESLSQWTNPSTMANAKVKLSIPKFKVEKMIDPKACLENLGLKHIFSED TSDFSGMSETKGVALSNVIHKVCLEITEDGGDSIEVPGARILQHKDELNADHPFIYIIRH NKTRNIIFFGKFCSP |
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| Pathways | |||||
| KEGG Pathway | p53 signaling pathway | ||||
| MicroRNAs in cancer | |||||
| PANTHER Pathway | p53 pathway | ||||
| Pathway Interaction Database | Direct p53 effectors | ||||
| ATF-2 transcription factor network | |||||
| Validated transcriptional targets of TAp63 isoforms | |||||
| References | |||||
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