Target Information

Target General Infomation
Target ID
T81103
Former ID
TTDI02255
Target Name
mRNA of Caspase-2
Gene Name
CASP2
Synonyms
CASP2 (mRNA); Caspase2 (mRNA); Caspase2 subunit p12 (mRNA); NEDD2 (mRNA); Neural precursor cell expressed developmentally downregulated protein 2 (mRNA); Protease ICH1 (mRNA); CASP2
Target Type
Clinical Trial
Disease Glaucoma [ICD9: 365; ICD10: H40-H42]
Function
Involved in the activation cascade of caspases responsible for apoptosis execution. Might function by either activating some proteins required for cell death or inactivating proteins necessary for cell survival.
BioChemical Class
Target of siRNA drug
UniProt ID
P42575
EC Number
EC 3.4.22.55
Sequence
MAAPSAGSWSTFQHKELMAADRGRRILGVCGMHPHHQETLKKNRVVLAKQLLLSELLEHL
LEKDIITLEMRELIQAKVGSFSQNVELLNLLPKRGPQAFDAFCEALRETKQGHLEDMLLT
TLSGLQHVLPPLSCDYDLSLPFPVCESCPLYKKLRLSTDTVEHSLDNKDGPVCLQVKPCT
PEFYQTHFQLAYRLQSRPRGLALVLSNVHFTGEKELEFRSGGDVDHSTLVTLFKLLGYDV
HVLCDQTAQEMQEKLQNFAQLPAHRVTDSCIVALLSHGVEGAIYGVDGKLLQLQEVFQLF
DNANCPSLQNKPKMFFIQACRGDETDRGVDQQDGKNHAGSPGCEESDAGKEKLPKMRLPT
RSDMICGYACLKGTAAMRNTKRGSWYIEALAQVFSERACDMHVADMLVKVNALIKDREGY
APGTEFHRCKEMSEYCSTLCRHLYLFPGHPPT
Drugs and Mode of Action
Drug(s) QPI-1007 Drug Info Phase 2/3 Glaucoma [525063]
Inhibitor compound 4 Drug Info [526447]
Pathways
NetPath Pathway TCR Signaling Pathway
IL4 Signaling Pathway
Pathway Interaction Database Negative effector of Fas and TNF-alpha
Caspase Cascade in Apoptosis
Reactome NOD1/2 Signaling Pathway
NADE modulates death signalling
WikiPathways Apoptosis Modulation by HSP70
Apoptosis
Parkinsons Disease Pathway
Signalling by NGF
Apoptosis Modulation and Signaling
References
Ref 525063ClinicalTrials.gov (NCT02341560) Phase II/III, Randomized, Sham-Controlled Trial of QPI-1007 in Subjects With Acute Non Arteritic Anterior Ischemic Optic Neuropathy (NAION). U.S. National Institutes of Health.
Ref 526447Identification of potent and selective small-molecule inhibitors of caspase-3 through the use of extended tethering and structure-based drug design. J Med Chem. 2002 Nov 7;45(23):5005-22.
Ref 532894Toxicological and pharmacokinetic properties of QPI-1007, a chemically modified synthetic siRNA targeting caspase 2 mRNA, following intravitreal injection. Nucleic Acid Ther. 2014 Aug;24(4):258-66.

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