Target General Infomation
Target ID
T84894
Former ID
TTDI03085
Target Name
Casein kinase 2
Target Type
Clinical Trial
Disease Cancer [ICD9: 140-229; ICD10: C00-C96]
Cervical cancer [ICD9: 180; ICD10: C53]
Drugs and Mode of Action
Drug(s) CIGB-300 Drug Info Phase 3 Cervical cancer [532981]
CX-4945 Drug Info Phase 1 Cancer [523166], [542980]
Modulator CIGB-300 Drug Info [532981]
CX-4945 Drug Info [532443]
Inhibitor compound 2 Drug Info [531356]
compound 5b Drug Info [532816]
Tetrabromocinnamic acid Drug Info [528551]
References
Ref 523166ClinicalTrials.gov (NCT01199718) Study of CX-4945 in Patients With Relapsed or Refractory Multiple Myeloma. U.S. National Institutes of Health.
Ref 532981Synergistic interactions of the anti-casein kinase 2 CIGB-300 peptide and chemotherapeutic agents in lung and cervical preclinical cancer models. Mol Clin Oncol. 2014 Nov;2(6):935-944. Epub 2014 Jul8.
Ref 542980(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 8126).
Ref 528551Tetrabromocinnamic acid (TBCA) and related compounds represent a new class of specific protein kinase CK2 inhibitors. Chembiochem. 2007 Jan 2;8(1):129-39.
Ref 5313566-amino-4-(pyrimidin-4-yl)pyridones: novel glycogen synthase kinase-3beta inhibitors. Bioorg Med Chem Lett. 2011 Mar 1;21(5):1429-33.
Ref 532443CX-4945, a selective inhibitor of casein kinase-2 (CK2), exhibits anti-tumor activity in hematologic malignancies including enhanced activity in chronic lymphocytic leukemia when combined with fludarabine and inhibitors of the B-cell receptor pathway. Leukemia. 2013 Oct;27(10):2094-6.
Ref 532816Potent and Selective Inhibitors of CK2 Kinase Identified through Structure-Guided Hybridization. ACS Med Chem Lett. 2012 Jan 24;3(4):278-83.
Ref 532981Synergistic interactions of the anti-casein kinase 2 CIGB-300 peptide and chemotherapeutic agents in lung and cervical preclinical cancer models. Mol Clin Oncol. 2014 Nov;2(6):935-944. Epub 2014 Jul8.

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