Target Information
| Target General Infomation | |||||
|---|---|---|---|---|---|
| Target ID |
T85188
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| Former ID |
TTDR00349
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| Target Name |
Reticulon 4 receptor
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| Gene Name |
RTN4R
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| Synonyms |
NgR; Nogo receptor; Nogo-66 receptor; UNQ330/PRO526; RTN4R
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| Target Type |
Research
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| Function |
Receptor for RTN4, OMG and MAG. Mediates axonal growth inhibition and may play a role in regulating axonal regeneration and plasticity in the adult central nervous system. Acts in conjunction with RTN4 and LIGO1 in regulating neuronal precursor cell motility during cortical development (By similarity).
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| BioChemical Class |
Transmembrane protein
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| UniProt ID | |||||
| Sequence |
MKRASAGGSRLLAWVLWLQAWQVAAPCPGACVCYNEPKVTTSCPQQGLQAVPVGIPAASQ
RIFLHGNRISHVPAASFRACRNLTILWLHSNVLARIDAAAFTGLALLEQLDLSDNAQLRS VDPATFHGLGRLHTLHLDRCGLQELGPGLFRGLAALQYLYLQDNALQALPDDTFRDLGNL THLFLHGNRISSVPERAFRGLHSLDRLLLHQNRVAHVHPHAFRDLGRLMTLYLFANNLSA LPTEALAPLRALQYLRLNDNPWVCDCRARPLWAWLQKFRGSSSEVPCSLPQRLAGRDLKR LAANDLQGCAVATGPYHPIWTGRATDEEPLGLPKCCQPDAADKASVLEPGRPASAGNALK GRVPPGDSPPGNGSGPRHINDSPFGTLPGSAEPPLTAVRPEGSEPPGFPTSGPRRRPGCS RKNRTRSHCRLGQAGSGGGGTGDSEGSGALPSLTCSLTPLGLALVLWTVLGPC |
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| Pathways | |||||
| Pathway Interaction Database | p75(NTR)-mediated signaling | ||||
| Reactome | Axonal growth inhibition (RHOA activation) | ||||
| WikiPathways | Spinal Cord Injury | ||||
| References | |||||
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