Target General Infomation
Target ID
T85223
Former ID
TTDR00828
Target Name
Deoxyribonuclease I
Gene Name
DNASE1
Synonyms
Alkaline deoxyribonuclease; DNase I; Dornase alfa; Herpesvirus alkaline DNase; Herpesvirus alkaline deoxyribonuclease; DNASE1
Target Type
Research
Function
Among other functions, seems to be involved in cell death by apoptosis. Binds specifically to G-actin and blocks actin polymerization (By similarity).
BioChemical Class
Endodeoxyribonucleases
UniProt ID
EC Number
EC 3.1.21.1
Sequence
MRGMKLLGALLALAALLQGAVSLKIAAFNIQTFGETKMSNATLVSYIVQILSRYDIALVQ
EVRDSHLTAVGKLLDNLNQDAPDTYHYVVSEPLGRNSYKERYLFVYRPDQVSAVDSYYYD
DGCEPCGNDTFNREPAIVRFFSRFTEVREFAIVPLHAAPGDAVAEIDALYDVYLDVQEKW
GLEDVMLMGDFNAGCSYVRPSQWSSIRLWTSPTFQWLIPDSADTTATPTHCAYDRIVVAG
MLLRGAVVPDSALPFNFQAAYGLSDQLAQAISDHYPVEVMLK
Inhibitor Alpha-D-Mannose Drug Info [551393]
References
Ref 551393How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6.

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