Target Information
| Target General Infomation | |||||
|---|---|---|---|---|---|
| Target ID |
T86152
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| Former ID |
TTDR00895
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| Target Name |
NH(3)-dependentNAD(+) synthetase
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| Gene Name |
efg
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| Synonyms |
Diphosphopyridine nucleotide synthetase; NAD synthase; NAD synthetase; NAD(+)-synthetase; NAD+ synthase; NAD+ synthetase; NadE; Nicotinamide adenine dinucleotide synthetase; Nitrogen-regulatory protein; efg
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| Target Type |
Research
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| Function |
Catalyzes a keystep in NAD biosynthesis, transforming deamido-NAD into NAD by a two-step reaction.
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| BioChemical Class |
Carbon-nitrogen ligase
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| UniProt ID | |||||
| EC Number |
EC 6.3.5.1
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| Sequence |
MTLQQQIIKALGAKPQINAEEEIRRSVDFLKSYLQTYPFIKSLVLGISGGQDSTLAGKLC
QMAINELRLETGNESLQFIAVRLPYGVQADEQDCQDAIAFIQPDRVLTVNIKGAVLASEQ ALREAGIELSDFVRGNEKARERMKAQYSIAGMTSGVVVGTDHAAEAITGFFTKYGDGGTD INPLYRLNKRQGKQLLAALACPEHLYKKAPTADLEDDRPSLPDEVALGVTYDNIDDYLEG KNVPQQVARTIENWYLKTEHKRRPPITVFDDFWKK |
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| Inhibitor | Alpha,Beta-Methyleneadenosine-5'-Triphosphate | Drug Info | [1] | ||
| Deamido-Nad+ | Drug Info | [1] | |||
| Diphosphate | Drug Info | [1] | |||
| Nicotinamide-Adenine-Dinucleotide | Drug Info | [1] | |||
| Pyrophosphate 2- | Drug Info | [2] | |||
| References | |||||
| REF 1 | How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. | ||||
| REF 2 | The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. | ||||
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