Target Information
Target General Infomation | |||||
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Target ID |
T86541
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Former ID |
TTDI02591
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Target Name |
Amiloride sensitive cation channel 1
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Gene Name |
ASIC2
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Synonyms |
Acidsensing ion channel 2; Amiloridesensitive brain sodium channel; Amiloridesensitive cation channel1, neuronal; Amiloridesensitive cation channelneuronal 1; BNC1; BNaC1; Brain sodium channel 1; Mammalian degenerin homolog; ASIC2
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Target Type |
Research
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Disease | Neuropathic pain [ICD9: 356.0, 356.8; ICD10: G64, G90.0] | ||||
Function |
Cation channel with high affinityfor sodium, which is gated by extracellular protons and inhibited by the diuretic amiloride. Also permeable for Li(+) and K(+). Generates a biphasic current with a fast inactivating and a slow sustained phase. Heteromeric channel assembly seems to modulate.
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BioChemical Class |
Amiloride-sensitive sodium channel
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UniProt ID | |||||
Sequence |
MDLKESPSEGSLQPSSIQIFANTSTLHGIRHIFVYGPLTIRRVLWAVAFVGSLGLLLVES
SERVSYYFSYQHVTKVDEVVAQSLVFPAVTLCNLNGFRFSRLTTNDLYHAGELLALLDVN LQIPDPHLADPSVLEALRQKANFKHYKPKQFSMLEFLHRVGHDLKDMMLYCKFKGQECGH QDFTTVFTKYGKCYMFNSGEDGKPLLTTVKGGTGNGLEIMLDIQQDEYLPIWGETEETTF EAGVKVQIHSQSEPPFIQELGFGVAPGFQTFVATQEQRLTYLPPPWGECRSSEMGLDFFP VYSITACRIDCETRYIVENCNCRMVHMPGDAPFCTPEQHKECAEPALGLLAEKDSNYCLC RTPCNLTRYNKELSMVKIPSKTSAKYLEKKFNKSEKYISENILVLDIFFEALNYETIEQK KAYEVAALLGDIGGQMGLFIGASILTILELFDYIYELIKEKLLDLLGKEEDEGSHDENVS TCDTMPNHSETISHTVNVPLQTTLGTLEEIAC |
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Pathways | |||||
KEGG Pathway | Taste transduction | ||||
Inflammatory mediator regulation of TRP channels | |||||
Reactome | Stimuli-sensing channels | ||||
WikiPathways | Iron uptake and transport | ||||
References |
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