Target General Infomation |
Target ID |
T89055
|
Former ID |
TTDNC00613
|
Target Name |
MEK-2 protein kinase
|
Gene Name |
MAP2K2
|
Synonyms |
Dual specificity mitogenactivated protein kinase kinase 2; ERK activator kinase 2; MAP kinase kinase 2; MAPK/ERK kinase 2; MAPKK 2; MEK 2; MAP2K2
|
Target Type |
Discontinued
|
Function |
Catalyzes the concomitant phosphorylation of a threonineand a tyrosine residue in a Thr-Glu-Tyr sequence located in MAP kinases. Activates the ERK1 and ERK2 MAP kinases (By similarity).
|
BioChemical Class |
Kinase
|
UniProt ID |
|
EC Number |
EC 2.7.12.2
|
Sequence |
MLARRKPVLPALTINPTIAEGPSPTSEGASEANLVDLQKKLEELELDEQQKKRLEAFLTQ KAKVGELKDDDFERISELGAGNGGVVTKVQHRPSGLIMARKLIHLEIKPAIRNQIIRELQ VLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKEAKRIPEEILGKVSIAVLRG LAYLREKHQIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMAPERLQ GTHYSVQSDIWSMGLSLVELAVGRYPIPPPDAKELEAIFGRPVVDGEEGEPHSISPRPRP PGRPVSGHGMDSRPAMAIFELLDYIVNEPPPKLPNGVFTPDFQEFVNKCLIKNPAERADL KMLTNHTFIKRSEVEEVDFAGWLCKTLRLNQPGTPTRTAV
|
Structure |
1S9I; 4H3Q
|
Drugs and Mode of Action |
Target Expression Profile (TEP) and Drug Resistance Mutation (DRM) |
Pathways |
References |
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