Target Information
| Target General Infomation | |||||
|---|---|---|---|---|---|
| Target ID |
T89082
|
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| Former ID |
TTDR00381
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| Target Name |
Hydroxymethylglutaryl-CoA synthase, mitochondrial
|
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| Gene Name |
HMGCS2
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| Synonyms |
3-hydroxy-3-methylglutaryl coenzyme A synthase; HMG-CoAsynthase; HMGCS2
|
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| Target Type |
Research
|
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| Function |
This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.
|
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| BioChemical Class |
Acyltransferase
|
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| UniProt ID | |||||
| EC Number |
EC 2.3.3.10
|
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| Sequence |
MQRLLTPVKRILQLTRAVQETSLTPARLLPVAHQRFSTASAVPLAKTDTWPKDVGILALE
VYFPAQYVDQTDLEKYNNVEAGKYTVGLGQTRMGFCSVQEDINSLCLTVVQRLMERIQLP WDSVGRLEVGTETIIDKSKAVKTVLMELFQDSGNTDIEGIDTTNACYGGTASLFNAANWM ESSSWDGRYAMVVCGDIAVYPSGNARPTGGAGAVAMLIGPKAPLALERGLRGTHMENVYD FYKPNLASEYPIVDGKLSIQCYLRALDRCYTSYRKKIQNQWKQAGSDRPFTLDDLQYMIF HTPFCKMVQKSLARLMFNDFLSASSDTQTSLYKGLEAFGGLKLEDTYTNKDLDKALLKAS QDMFDKKTKASLYLSTHNGNMYTSSLYGCLASLLSHHSAQELAGSRIGAFSYGSGLAASF FSFRVSQDAAPGSPLDKLVSSTSDLPKRLASRKCVSPEEFTEIMNQREQFYHKVNFSPPG DTNSLFPGTWYLERVDEQHRRKYARRPV |
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| Pathways | |||||
| BioCyc Pathway | Superpathway of geranylgeranyldiphosphate biosynthesis I (via mevalonate) | ||||
| Superpathway of cholesterol biosynthesis | |||||
| Mevalonate pathway | |||||
| Ketogenesis | |||||
| KEGG Pathway | Synthesis and degradation of ketone bodies | ||||
| Valine, leucine and isoleucine degradation | |||||
| Butanoate metabolism | |||||
| Terpenoid backbone biosynthesis | |||||
| Metabolic pathways | |||||
| Biosynthesis of antibiotics | |||||
| PPAR signaling pathway | |||||
| Pathway Interaction Database | Validated targets of C-MYC transcriptional repression | ||||
| PathWhiz Pathway | Butyrate Metabolism | ||||
| Ketone Body Metabolism | |||||
| Valine, Leucine and Isoleucine Degradation | |||||
| Circadian clock | |||||
| Reactome | PPARA activates gene expression | ||||
| WikiPathways | Synthesis and Degradation of Ketone Bodies | ||||
| Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) | |||||
| Fatty acid, triacylglycerol, and ketone body metabolism | |||||
| References | |||||
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