Target Information
| Target General Infomation | |||||
|---|---|---|---|---|---|
| Target ID |
T94692
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| Former ID |
TTDR00225
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| Target Name |
Low-density lipoprotein receptor
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| Gene Name |
LDLR
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| Synonyms |
LDL receptor; LDLR
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| Target Type |
Successful
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| Disease | Non-small cell lung cancer [ICD10: C33-C34] | ||||
| Function |
Binds ldl, the major cholesterol-carrying lipoprotein of plasma, and transports it into cells by endocytosis. In order to be internalized, the receptor-ligand complexes must first cluster into clathrin-coated pits.
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| BioChemical Class |
LDLR family
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| UniProt ID | |||||
| Sequence |
MGPWGWKLRWTVALLLAAAGTAVGDRCERNEFQCQDGKCISYKWVCDGSAECQDGSDESQ
ETCLSVTCKSGDFSCGGRVNRCIPQFWRCDGQVDCDNGSDEQGCPPKTCSQDEFRCHDGK CISRQFVCDSDRDCLDGSDEASCPVLTCGPASFQCNSSTCIPQLWACDNDPDCEDGSDEW PQRCRGLYVFQGDSSPCSAFEFHCLSGECIHSSWRCDGGPDCKDKSDEENCAVATCRPDE FQCSDGNCIHGSRQCDREYDCKDMSDEVGCVNVTLCEGPNKFKCHSGECITLDKVCNMAR DCRDWSDEPIKECGTNECLDNNGGCSHVCNDLKIGYECLCPDGFQLVAQRRCEDIDECQD PDTCSQLCVNLEGGYKCQCEEGFQLDPHTKACKAVGSIAYLFFTNRHEVRKMTLDRSEYT SLIPNLRNVVALDTEVASNRIYWSDLSQRMICSTQLDRAHGVSSYDTVISRDIQAPDGLA VDWIHSNIYWTDSVLGTVSVADTKGVKRKTLFRENGSKPRAIVVDPVHGFMYWTDWGTPA KIKKGGLNGVDIYSLVTENIQWPNGITLDLLSGRLYWVDSKLHSISSIDVNGGNRKTILE DEKRLAHPFSLAVFEDKVFWTDIINEAIFSANRLTGSDVNLLAENLLSPEDMVLFHNLTQ PRGVNWCERTTLSNGGCQYLCLPAPQINPHSPKFTCACPDGMLLARDMRSCLTEAEAAVA TQETSTVRLKVSSTAVRTQHTTTRPVPDTSRLPGATPGLTTVEIVTMSHQALGDVAGRGN EKKPSSVRALSIVLPIVLLVFLCLGVFLLWKNWRLKNINSINFDNPVYQKTTEDEVHICH NQDGYSYPSRQMVSLEDDVA |
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| Structure |
1AJJ; 1D2J; 1F5Y; 1F8Z; 1HJ7; 1HZ8; 1I0U; 1IJQ; 1LDL; 1LDR; 1LRX; 1N7D; 1XFE; 2FCW; 2KRI; 2LGP; 2M7P; 2MG9; 2W2M; 2W2N; 2W2O; 2W2P; 2W2Q; 3BPS; 3GCW; 3GCX; 3M0C; 3P5B; 3P5C; 3SO6; 4NE9
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| Drugs and Mode of Action | |||||
| Target Expression Profile (TEP) and Drug Resistance Mutation (DRM) | |||||
| TEP | EXP Info | ||||
| Pathways | |||||
| KEGG Pathway | Endocytosis | ||||
| Ovarian steroidogenesis | |||||
| Bile secretion | |||||
| Toxoplasmosis | |||||
| Hepatitis C | |||||
| NetPath Pathway | FSH Signaling Pathway | ||||
| IL2 Signaling Pathway | |||||
| Reactome | LDL-mediated lipid transport | ||||
| Chylomicron-mediated lipid transport | |||||
| Retinoid metabolism and transport | |||||
| WikiPathways | DNA Damage Response (only ATM dependent) | ||||
| Statin Pathway | |||||
| Wnt Signaling Pathway | |||||
| Wnt Signaling Pathway and Pluripotency | |||||
| Visual phototransduction | |||||
| Lipid digestion, mobilization, and transport | |||||
| Oncostatin M Signaling Pathway | |||||
| SREBF and miR33 in cholesterol and lipid homeostasis | |||||
| SREBP signalling | |||||
| Folate Metabolism | |||||
| Vitamin B12 Metabolism | |||||
| Selenium Micronutrient Network | |||||
| References | |||||
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