Target Information
Target General Infomation | |||||
---|---|---|---|---|---|
Target ID |
T95139
|
||||
Former ID |
TTDR00070
|
||||
Target Name |
Cysteine protease
|
||||
Target Type |
Successful
|
||||
Disease | Trypanosomiasis [ICD9: 086.5-086; ICD10: B56-B57] | ||||
Target Validation |
T95139
|
||||
Drugs and Mode of Action | |||||
Inhibitor | ALLICIN | Drug Info | [531093] | ||
K-777 | Drug Info | [530398] | |||
MELARSOPROL | Drug Info | [530346] | |||
N-methyl-Pip-F-homoF-vinyl sulfonyl phenyl (N-methyl-Pip-F-hF-VS phi) | Drug Info | [536476] | |||
S-benzyl phenylmethanesulfinothioate | Drug Info | [531093] | |||
S-hexyl hexane-1-sulfinothioate | Drug Info | [531093] | |||
S-isopentyl 3-methylbutane-1-sulfinothioate | Drug Info | [531093] | |||
S-propyl propane-1-sulfinothioate | Drug Info | [531093] | |||
References | |||||
Ref 530346 | J Med Chem. 2009 Sep 24;52(18):5662-72.On-bead screening of a combinatorial fumaric acid derived peptide library yields antiplasmodial cysteine protease inhibitors with unusual peptide sequences. | ||||
Ref 530398 | Bioorg Med Chem Lett. 2009 Nov 1;19(21):6218-21. Epub 2009 Sep 3.Novel non-peptidic vinylsulfones targeting the S2 and S3 subsites of parasite cysteine proteases. |
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.