Target Information

Target General Infomation
Target ID
T96916
Target Name
Dickkopf-3
Gene Name
DKK3
Synonyms
DKK3
Target Type
Clinical Trial
Disease Prostate cancer [ICD9: 185; ICD10: C61]
UniProt ID
Q9UBP4
Sequence
MQRLGATLLCLLLAAAVPTAPAPAPTATSAPVKPGPALSYPQEEATLNEMFREVEELMED
TQHKLRSAVEEMEAEEAAAKASSEVNLANLPPSYHNETNTDTKVGNNTIHVHREIHKITN
NQTGQMVFSETVITSVGDEEGRRSHECIIDEDCGPSMYCQFASFQYTCQPCRGQRMLCTR
DSECCGDQLCVWGHCTKMATRGSNGTICDNQRDCQPGLCCAFQRGLLFPVCTPLPVEGEL
CHDPASRLLDLITWELEPDGALDRCPCASGLLCQPHSHSLVYVCKPTFVGSRDQDGEILL
PREVPDEYEVGSFMEEVRQELEDLERSLTEEMALREPAAAAAALLGGEEI
Drugs and Mode of Action
Drug(s) REIC gene therapy Drug Info Phase 1/2 Prostate cancer [524416]
Modulator REIC gene therapy Drug Info [532606]
Target Expression Profile (TEP) and Drug Resistance Mutation (DRM)
TEP EXP Info
References
Ref 524416ClinicalTrials.gov (NCT01931046) Study of a Recombinant Adenovirus to Treat Localized Prostate Cancer. U.S. National Institutes of Health.
Ref 532606Potential of adenovirus-mediated REIC/Dkk-3 gene therapy for use in the treatment of pancreatic cancer. J Gastroenterol Hepatol. 2014 May;29(5):973-83.

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