Drug General Information
Drug ID	D00AUX
Former ID	DNCL002894
Drug Name	MSDC-0602
Drug Type	Small molecular drug
Indication	Type 2 diabetes [ICD9: 250; ICD10:E11]		Phase 2	[523326]
Company	Metabolic Solutions Development
Structure		Download 2D MOL 3D MOL
Formula	C19H17NO5S
PubChem Compound ID	25230266
Target and Pathway
Target(s)	Insulin receptor	Target Info	Modulator	[531918]
KEGG Pathway	Ras signaling pathway
	Rap1 signaling pathway
	cGMP-PKG signaling pathway
	HIF-1 signaling pathway
	FoxO signaling pathway
	PI3K-Akt signaling pathway
	AMPK signaling pathway
	Adherens junction
	Insulin signaling pathway
	Ovarian steroidogenesis
	Type II diabetes mellitus
	Non-alcoholic fatty liver disease (NAFLD)
	Aldosterone-regulated sodium reabsorption
NetPath Pathway	TGF_beta_Receptor Signaling Pathway
PANTHER Pathway	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade
	Insulin/IGF pathway-protein kinase B signaling cascade
	PI3 kinase pathway
Pathway Interaction Database	Insulin Pathway
	Signaling events mediated by PTP1B
	Signaling events mediated by TCPTP
	Insulin-mediated glucose transport
PathWhiz Pathway	Insulin Signalling
	Leucine Stimulation on Insulin Signaling
Reactome	IRS activation
	Signal attenuation
	Insulin receptor signalling cascade
	Insulin receptor recycling
WikiPathways	DNA Damage Response (only ATM dependent)
	Insulin Signaling
	Nanoparticle triggered autophagic cell death
	AGE/RAGE pathway
	Signaling by Insulin receptor
	Folate Metabolism
	Type II diabetes mellitus
	Vitamin B12 Metabolism
	Selenium Micronutrient Network
	AMPK Signaling
References
Ref 523326	ClinicalTrials.gov (NCT01280695) A Randomized, Double-Blind, Comparator- and Placebo-Controlled, Multiple-Dose Study to Evaluate the Safety, Tolerability and Efficacy of Three Dose Levels of MSDC-0602 in Type 2 Diabetic Patients. U.S. National Institutes of Health.
Ref 531918	Insulin resistance and metabolic derangements in obese mice are ameliorated by a novel peroxisome proliferator-activated receptor gamma-sparing thiazolidinedione. J Biol Chem. 2012 Jul 6;287(28):23537-48.

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