Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D00CKQ
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| Former ID |
DIB012972
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| Drug Name |
TRPV1 antagonists
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| Synonyms |
TRPV1 antagonists (pain); TRPV1 antagonists (pain), Merck & Co; TRPV1 antagonists (pain), Schering-Plough; Transient receptor potential vanilloid receptor-1 antagonists (pain), Merck & Co; Transient receptor potential vanilloid receptor-1 antagonists (pain), Schering-Plough
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| Indication | Pain [ICD9: 338, 356.0, 356.8,780; ICD10:G64, G90.0, R52, G89] | Investigative | [1] | ||
| Company |
Schering-Plough Corp
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| Structure |
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Download2D MOL |
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| Canonical SMILES |
c1(ccc(cc1)C(F)(F)F)c1onc(c1CNCC(C)C)C(=O)N[C@H]1C[C@H]<br />(CCC1)O
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| Target and Pathway | |||||
| Target(s) | Vanilloid receptor 1 | Target Info | Antagonist | [2] | |
| KEGG Pathway | Neuroactive ligand-receptor interaction | ||||
| Inflammatory mediator regulation of TRP channels | |||||
| NetPath Pathway | IL2 Signaling Pathway | ||||
| Pathway Interaction Database | Trk receptor signaling mediated by the MAPK pathway | ||||
| Trk receptor signaling mediated by PI3K and PLC-gamma | |||||
| Reactome | TRP channels | ||||
| References | |||||
| REF 1 | TRPV1 antagonists as potential antitussive agents. Lung. 2008;186 Suppl 1:S59-65. Epub 2007 Oct 10. | ||||
| REF 2 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 507). | ||||
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