Drug Information

Drug General Information
Drug ID
D00CMV
Former ID
DCL000027
Drug Name
ABT-102
Synonyms
3-(1H-indazol-4-yl)-1-(5-tert-butyl-2,3-dihydro-1H-inden-1-yl)urea
Drug Type
Small molecular drug
Indication Chronic pathological pain [ICD9: 338,780; ICD10:R52, G89] Phase 1 [522601]
Therapeutic Class
Analgesics
Company
Abbott
Structure
Download
2D MOL

3D MOL
Formula
C21H24N4O
Canonical SMILES
CC(C)(C)C1=CC2=C(C=C1)C(CC2)NC(=O)NC3=CC=CC4=C3C=NN4
InChI
1S/C21H24N4O/c1-21(2,3)14-8-9-15-13(11-14)7-10-18(15)24-20(26)23-17-5-4-6-19-16(17)12-22-25-19/h4-6,8-9,11-12,18H,7,10H2,1-3H3,(H,22,25)(H2,23,24,26)/t18-/m1/s1
InChIKey
TYOYXJNGINZFET-GOSISDBHSA-N
PubChem Compound ID
11256560
PubChem Substance ID
16341965, 23432753, 42336087, 77600649, 103556133, 104055394, 124759153, 134338738, 135263496, 136349995, 144115527, 152040091, 152344286, 223913506, 228028137, 247217644, 247455199, 252160203
Target and Pathway
Target(s) Vanilloid receptor 1 Target Info Blocker [537396]
KEGG Pathway Neuroactive ligand-receptor interaction
Inflammatory mediator regulation of TRP channels
NetPath Pathway IL2 Signaling Pathway
Pathway Interaction Database Trk receptor signaling mediated by the MAPK pathway
Trk receptor signaling mediated by PI3K and PLC-gamma
Reactome TRP channels
References
Ref 522601ClinicalTrials.gov (NCT00854659) A Safety, Tolerability and Pharmacokinetic Study of ABT-102 in Healthy Subjects. U.S. National Institutes of Health.
Ref 537396Analgesic potential of TRPV1 antagonists. Biochem Pharmacol. 2009 Aug 1;78(3):211-6. Epub 2009 Mar 5.

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