Drug Information

Drug General Information
Drug ID
D00DZY
Former ID
DNC006780
Drug Name
4-(2-benzenesulfonylphenyl)piperazine
Drug Type
Small molecular drug
Indication Discovery agent Investigative [528373]
Structure
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2D MOL

3D MOL
Formula
C16H18N2O2S
Canonical SMILES
C1CN(CCN1)C2=CC=CC=C2S(=O)(=O)C3=CC=CC=C3
InChI
1S/C16H18N2O2S/c19-21(20,14-6-2-1-3-7-14)16-9-5-4-8-15(16)18-12-10-17-11-13-18/h1-9,17H,10-13H2
InChIKey
QHMSQHVDMJCBCI-UHFFFAOYSA-N
PubChem Compound ID
11849201
Target and Pathway
Target(s) 5-hydroxytryptamine 6 receptor Target Info Inhibitor [528373]
KEGG Pathway Calcium signaling pathway
cAMP signaling pathway
Neuroactive ligand-receptor interaction
Serotonergic synapse
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
PathWhiz Pathway Excitatory Neural Signalling Through 5-HTR 6 and Serotonin
Reactome Serotonin receptors
G alpha (s) signalling events
WikiPathways Serotonin Receptor 4/6/7 and NR3C Signaling
Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
GPCR ligand binding
GPCR downstream signaling
References
Ref 528373J Med Chem. 2006 Aug 24;49(17):5217-25.Binding of sulfonyl-containing arylalkylamines at human 5-HT6 serotonin receptors.
Ref 528373J Med Chem. 2006 Aug 24;49(17):5217-25.Binding of sulfonyl-containing arylalkylamines at human 5-HT6 serotonin receptors.

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