Drug Information
Drug General Information | |||||
---|---|---|---|---|---|
Drug ID |
D00ECO
|
||||
Former ID |
DNC001327
|
||||
Drug Name |
SIB-1553A
|
||||
Drug Type |
Small molecular drug
|
||||
Indication | Alzheimer disease [ICD9: 331; ICD10:G30] | Discontinued in Phase 2 | [546683] | ||
Structure |
Download2D MOL |
||||
Formula |
C13H20ClNOS
|
||||
Canonical SMILES |
CN1CCCC1CCSC2=CC=C(C=C2)O.Cl
|
||||
InChI |
1S/C13H19NOS.ClH/c1-14-9-2-3-11(14)8-10-16-13-6-4-12(15)5-7-13;/h4-7,11,15H,2-3,8-10H2,1H3;1H
|
||||
InChIKey |
RJSVKPQKXSMZMT-UHFFFAOYSA-N
|
||||
CAS Number |
CAS 205887-54-3
|
||||
PubChem Compound ID | |||||
PubChem Substance ID | |||||
Target and Pathway | |||||
Target(s) | Nicotinic acetylcholine receptor | Target Info | Agonist | [538102] | |
Neuronal acetylcholine receptor protein, beta-4 chain | Target Info | Agonist | [535261] | ||
References | |||||
Ref 535261 | SIB-1553A, (+/-)-4-[[2-(1-methyl-2-pyrrolidinyl)ethyl]thio]phenol hydrochloride, a subtype-selective ligand for nicotinic acetylcholine receptors with putative cognitive-enhancing properties: effectson working and reference memory performances in aged rodents and nonhuman primates. J Pharmacol Exp Ther. 2001 Oct;299(1):297-306. | ||||
Ref 538102 | The potential of subtype-selective neuronal nicotinic acetylcholine receptor agonists as therapeutic agents. Life Sci. 1998;62(17-18):1601-6. |
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.