Drug Information

Drug General Information
Drug ID
D00EMF
Former ID
DIB020905
Drug Name
SB 242084
Synonyms
SB-242,084; SB242084
Drug Type
Small molecular drug
Indication Discovery agent Investigative [539229]
Structure
Download
2D MOL
Formula
C21H19ClN4O2
InChI
InChI=1S/C21H19ClN4O2/c1-13-10-15-7-9-26(18(15)11-17(13)22)21(27)25-16-5-6-20(24-12-16)28-19-4-3-8-23-14(19)2/h3-6,8,10-12H,7,9H2,1-2H3,(H,25,27)
InChIKey
GIUZEIJUFOPTMR-UHFFFAOYSA-N
PubChem Compound ID
3644637
PubChem Substance ID
4970033, 7980573, 9825379, 14780982, 37840154, 47583782, 48179769, 52522852, 57356452, 85209288, 90341546, 92729667, 103176822, 103956179, 112084110, 124896722, 125333632, 127960163, 135650998, 136351197, 144239949, 164233608, 185989922, 223393645, 223532850, 226821862
Target and Pathway
Target(s) 5-hydroxytryptamine 2C receptor Target Info Antagonist [534428]
5-hydroxytryptamine 2A receptor Target Info Antagonist [534428]
5-hydroxytryptamine 2B receptor Target Info Antagonist [534428]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Gap junction
Serotonergic synapse
Inflammatory mediator regulation of TRP channelshsa04020:Calcium signaling pathway
Inflammatory mediator regulation of TRP channels
PANTHER Pathway 5HT2 type receptor mediated signaling pathwayP04374:5HT2 type receptor mediated signaling pathwayP04374:5HT2 type receptor mediated signaling pathway
Reactome Serotonin receptors
G alpha (q) signalling eventsR-HSA-390666:Serotonin receptors
G alpha (q) signalling events
WikiPathways Serotonin Receptor 2 and ELK-SRF/GATA4 signaling
Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
GPCR ligand binding
GPCR downstream signalingWP733:Serotonin Receptor 2 and STAT3 Signaling
SIDS Susceptibility Pathways
GPCR downstream signaling
GPCRs, OtherWP732:Serotonin Receptor 2 and ELK-SRF/GATA4 signaling
References
Ref 539229(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 193).
Ref 534428SB 242084, a selective and brain penetrant 5-HT2C receptor antagonist. Neuropharmacology. 1997 Apr-May;36(4-5):609-20.

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