Drug Information
Drug General Information | |||||
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Drug ID |
D00GNK
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Former ID |
DCL000156
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Drug Name |
LY293111
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Drug Type |
Small molecular drug
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Therapeutic Class |
Anticancer Agents
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Company |
Sawyer & Brooks
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Structure |
Download2D MOL |
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Formula |
C33H33FO6
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InChI |
InChI=1S/C33H33FO6/c1-3-9-25-29(12-7-13-30(25)40-31-11-6-5-10-26(31)33(36)37)38-18-8-19-39-32-21-28(35)27(20-22(32)4-2)23-14-16-24(34)17-15-23/h5-7,10-17,20-21,35H,3-4,8-9,18-19H2,1-2H3,(H,36,37)
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InChIKey |
YFIZRWPXUYFCSN-UHFFFAOYSA-N
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CAS Number |
CAS 161172-51-6
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PubChem Compound ID | |||||
PubChem Substance ID | |||||
Target and Pathway | |||||
Target(s) | Leukotriene B4 receptor 1 | Target Info | Antagonist | [536139], [536318], [537053] | |
KEGG Pathway | Neuroactive ligand-receptor interaction | ||||
NetPath Pathway | IL4 Signaling Pathway | ||||
References | |||||
Ref 539959 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2948). | ||||
Ref 545441 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800003262) | ||||
Ref 536139 | Leukotriene B4 receptor inhibitor LY293111 induces cell cycle arrest and apoptosis in human anaplastic large-cell lymphoma cells via JNK phosphorylation. Leukemia. 2005 Nov;19(11):1977-84. | ||||
Ref 536318 | A phase I study of oral LY293111 given daily in combination with irinotecan in patients with solid tumours. Invest New Drugs. 2007 Jun;25(3):217-25. Epub 2006 Dec 5. | ||||
Ref 537053 | The Role of PPARgamma Receptors and Leukotriene B(4) Receptors in Mediating the Effects of LY293111 in Pancreatic Cancer. PPAR Res. 2008;2008:827096. Epub 2009 Jan 27. |
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