Drug Information

Drug General Information
Drug ID
D00GOY
Former ID
DNC003703
Drug Name
VER-3323
Drug Type
Small molecular drug
Indication Discovery agent Investigative [539041]
Structure
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2D MOL

3D MOL
Formula
C11H15BrN2
InChI
InChI=1S/C11H15BrN2/c1-8(13)7-14-5-4-9-2-3-10(12)6-11(9)14/h2-3,6,8H,4-5,7,13H2,1H3/t8-/m0/s1
InChIKey
QGRQJMXAQYGAKK-QMMMGPOBSA-N
PubChem Compound ID
6604042
PubChem Substance ID
11111954, 11646433, 15490354, 43223832, 48243346, 50076878, 50111107, 52006272, 90340999, 103278753, 104033865, 114637149, 124749895, 126718892, 129020430, 134340908, 135651304, 142037904, 179235929, 233262649
Target and Pathway
Target(s) 5-hydroxytryptamine 2B receptor Target Info Inhibitor [527037]
5-hydroxytryptamine 2A receptor Target Info Inhibitor [527037]
5-hydroxytryptamine 2C receptor Target Info Inhibitor [527037]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Gap junction
Serotonergic synapse
Inflammatory mediator regulation of TRP channelshsa04020:Calcium signaling pathway
Inflammatory mediator regulation of TRP channels
PANTHER Pathway 5HT2 type receptor mediated signaling pathwayP04374:5HT2 type receptor mediated signaling pathwayP04374:5HT2 type receptor mediated signaling pathway
Reactome Serotonin receptors
G alpha (q) signalling eventsR-HSA-390666:Serotonin receptors
G alpha (q) signalling events
WikiPathways Serotonin Receptor 2 and ELK-SRF/GATA4 signaling
Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
GPCR ligand binding
GPCR downstream signalingWP733:Serotonin Receptor 2 and STAT3 Signaling
SIDS Susceptibility Pathways
GPCR downstream signaling
GPCRs, OtherWP732:Serotonin Receptor 2 and ELK-SRF/GATA4 signaling
References
Ref 539041(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 168).
Ref 527037Bioorg Med Chem Lett. 2004 May 3;14(9):2367-70.Indoline derivatives as 5-HT(2C) receptor agonists.

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