Drug Information

Drug General Information
Drug ID
D00IUG
Former ID
DAP000303
Drug Name
Levobunolol
Synonyms
Akbeta; Betagan; Levobunololum; Levobunolol HCl; Betegan (TN); Levobunolol (INN); Levobunolol [INN:BAN]; Levobunololum [INN-Latin]; Liquifilm (TN); W-6412A; W-7000A; AK-Beta (TN); (-)-Bunolol; (S)-5-(3-((1,1-dimethylethyl)amino)-2-hydroxypropoxy)-3,4-dihydro-1(2H)-naphthalenone; 5-[(2S)-3-(tert-butylamino)-2-hydroxypropoxy]-3,4-dihydro-2H-naphthalen-1-one; 5-[(2S)-3-(tert-butylamino)-2-hydroxypropoxy]-3,4-dihydronaphthalen-1(2H)-one
Drug Type
Small molecular drug
Indication Open-angle glaucoma [ICD9: 365; ICD10:H40-H42] Approved [536361], [541042]
Therapeutic Class
Sympatholytics
Company
Allergan Pharmaceuticals
Structure
Download
2D MOL

3D MOL
Formula
C17H25NO3
InChI
InChI=1S/C17H25NO3/c1-17(2,3)18-10-12(19)11-21-16-9-5-6-13-14(16)7-4-8-15(13)20/h5-6,9,12,18-19H,4,7-8,10-11H2,1-3H3/t12-/m0/s1
InChIKey
IXHBTMCLRNMKHZ-LBPRGKRZSA-N
CAS Number
CAS 47141-42-4
PubChem Compound ID
39468
PubChem Substance ID
10116, 7979771, 8147013, 8176045, 11112712, 11112713, 11466875, 11467995, 11486490, 14800093, 34705356, 46507518, 47216948, 47440435, 47810938, 47810939, 49698660, 50064797, 50100511, 57312300, 75377008, 85787332, 96024805, 104331810, 117598030, 123099352, 128233843, 134223509, 134337615, 135002286, 135650031, 137004994, 141191903, 160964543, 162172878, 163418962, 163851154, 164789572, 172860923, 175268158, 179150487, 184531333, 198967741, 223554927, 224987628, 226412538, 252351251
ChEBI ID
ChEBI:6438
SuperDrug ATC ID
S01ED03
SuperDrug CAS ID
cas=047141424
Target and Pathway
Target(s) Beta-1 adrenergic receptor Target Info Antagonist [537782]
KEGG Pathway Calcium signaling pathway
cGMP-PKG signaling pathway
cAMP signaling pathway
Neuroactive ligand-receptor interaction
Endocytosis
Adrenergic signaling in cardiomyocytes
Gap junction
Salivary secretion
Dilated cardiomyopathy
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Beta1 adrenergic receptor signaling pathway
PathWhiz Pathway Muscle/Heart Contraction
Reactome Adrenoceptors
G alpha (s) signalling events
WikiPathways Monoamine GPCRs
Calcium Regulation in the Cardiac Cell
GPCRs, Class A Rhodopsin-like
Endothelin Pathways
GPCR ligand binding
GPCR downstream signaling
References
Ref 536361Natural products as sources of new drugs over the last 25 years. J Nat Prod. 2007 Mar;70(3):461-77. Epub 2007 Feb 20.
Ref 541042(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 570).
Ref 537782Binding of beta-adrenoceptor antagonists to rat and rabbit lung: special reference to levobunolol. Arzneimittelforschung. 1984;34(5):579-84.

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