| Drug General Information |
| Drug ID |
D00JMZ
|
| Former ID |
DNC011785
|
| Drug Name |
CGS-27830
|
| Drug Type |
Small molecular drug
|
| Indication |
Discovery agent
|
Terminated |
[1]
|
|---|
| Structure |
|
Download
2D MOL
3D MOL
|
| Formula |
C32H30N4O11
|
| Canonical SMILES |
CC1=C(C(C(=C(N1)C)C(=O)OC(=O)C2=C(NC(=C(C2C3=CC(=CC=C3)<br />[N+](=O)[O-])C(=O)OC)C)C)C4=CC(=CC=C4)[N+](=O)[O-])C(=O<br />)OC
|
| InChI |
1S/C32H30N4O11/c1-15-23(29(37)45-5)27(19-9-7-11-21(13-19)35(41)42)25(17(3)33-15)31(39)47-32(40)26-18(4)34-16(2)24(30(38)46-6)28(26)20-10-8-12-22(14-20)36(43)44/h7-14,27-28,33-34H,1-6H3/t27-,28+
|
| InChIKey |
PZNZOWSLQRURNA-HNRBIFIRSA-N
|
| PubChem Compound ID |
|
| Target and Pathway |
| Target(s) |
Voltage-dependent L-type calcium channel alpha-1D subunit |
Target Info |
Inhibitor |
[2]
|
|---|
| Voltage-dependent L-type calcium channel subunit alpha-1C |
Target Info |
Inhibitor |
[2]
|
|
KEGG Pathway
|
MAPK signaling pathway
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Calcium signaling pathway
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cGMP-PKG signaling pathway
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cAMP signaling pathway
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Cardiac muscle contraction
|
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Adrenergic signaling in cardiomyocytes
|
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Vascular smooth muscle contraction
|
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Circadian entrainment
|
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Retrograde endocannabinoid signaling
|
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Glutamatergic synapse
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Cholinergic synapse
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Serotonergic synapse
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GABAergic synapse
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Dopaminergic synapse
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Insulin secretion
|
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GnRH signaling pathway
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Oxytocin signaling pathway
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Type II diabetes mellitus
|
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Carbohydrate digestion and absorption
|
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Alzheimer's disease
|
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Amphetamine addiction
|
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Hypertrophic cardiomyopathy (HCM)
|
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Arrhythmogenic right ventricular cardiomyopathy (ARVC)
|
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Dilated cardiomyopathyhsa04010:MAPK signaling pathway
|
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Long-term potentiation
|
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Dilated cardiomyopathy
|
|
NetPath Pathway
|
IL2 Signaling Pathway
|
|
PANTHER Pathway
|
Alzheimer disease-amyloid secretase pathway
|
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Nicotinic acetylcholine receptor signaling pathway
|
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5HT2 type receptor mediated signaling pathway
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Beta1 adrenergic receptor signaling pathway
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Beta2 adrenergic receptor signaling pathway
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Oxytocin receptor mediated signaling pathwayP00003:Alzheimer disease-amyloid secretase pathway
|
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Oxytocin receptor mediated signaling pathway
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Nicotine pharmacodynamics pathway
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PathWhiz Pathway
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Muscle/Heart Contraction
|
|
Reactome
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Adrenaline,noradrenaline inhibits insulin secretion
|
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NCAM1 interactions
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Regulation of insulin secretionR-HSA-400042:Adrenaline,noradrenaline inhibits insulin secretion
|
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Regulation of insulin secretion
|
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WikiPathways
|
Calcium Regulation in the Cardiac Cell
|
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Arrhythmogenic Right Ventricular Cardiomyopathy
|
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Alzheimers Disease
|
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NCAM signaling for neurite out-growth
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Integration of energy metabolismWP536:Calcium Regulation in the Cardiac Cell
|
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Integration of energy metabolism
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Nicotine Activity on Chromaffin Cells
|
| References |
| REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800004940) |
|---|
| REF 2 | CGS 27830, a potent nonpeptide endothelin receptor antagonist, Bioorg. Med. Chem. Lett. 3(10):2099-2104 (1993). |
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