Drug General Information
Drug ID	D00KQT
Former ID	DIB011092
Drug Name	FR-129169
Indication	Arteriosclerosis [ICD9: 440; ICD10:I70]		Terminated	[545283]
Company	Fujisawa Pharmaceutical Co Ltd
Structure		Download 2D MOL 3D MOL
Canonical SMILES	C(=O)(NC(Cc1ccccc1)c1ccccc1)Cc1c(OCCCCCCCC)cccc1
CAS Number	CAS 143895-84-5
Target and Pathway
Target(s)	Liver carboxylesterase	Target Info	Modulator	[534219]
KEGG Pathway	Drug metabolism - other enzymes
	Metabolic pathways
Pathway Interaction Database	E2F transcription factor network
WikiPathways	NRF2 pathway
	Nuclear Receptors Meta-Pathway
	Heroin metabolism
	Irinotecan Pathway
	Fluoropyrimidine Activity
	Phase I biotransformations, non P450
References
Ref 545283	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800002683)
Ref 534219	Plasma cholesterol reducing effect of FR129169, a novel acyl-CoA:cholesterol acyltransferase inhibitor, in the rat. Jpn J Pharmacol. 1996 Jan;70(1):35-41.

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