Drug General Information
Drug ID
D00LBX
Former ID
DNC000319
Drug Name
Bicuculline
Drug Type
Small molecular drug
Indication Discovery agent Investigative [539464]
Structure
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2D MOL

3D MOL

Formula
C20H17NO6
InChI
InChI=1S/C20H17NO6/c1-21-5-4-10-6-14-15(25-8-24-14)7-12(10)17(21)18-11-2-3-13-19(26-9-23-13)16(11)20(22)27-18/h2-3,6-7,17-18H,4-5,8-9H2,1H3/t17-,18+/m0/s1
InChIKey
IYGYMKDQCDOMRE-ZWKOTPCHSA-N
CAS Number
CAS 485-49-4
PubChem Compound ID
PubChem Substance ID
SuperDrug ATC ID
A02BC05
SuperDrug CAS ID
cas=161973100
Target and Pathway
Target(s) Gamma-aminobutyric acid receptor Target Info Antagonist [534920]
Glutamate receptor AMPA subtype Target Info Antagonist [535600]
References
Ref 539464(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2312).
Ref 534920GABA receptors inhibited by benzodiazepines mediate fast inhibitory transmission in the central amygdala. J Neurosci. 1999 Nov 15;19(22):9698-704.
Ref 535600Effects of subcutaneous administration of the gamma-aminobutyric acid(A) receptor agonist muscimol on water intake in water-deprived rats. Physiol Behav. 2002 Nov;77(2-3):445-50.

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