Drug General Information
Drug ID	D00MFV
Former ID	DNC008830
Drug Name	9-(sec-Butyl)-9H-adenine
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[530014]
Structure		Download 2D MOL 3D MOL
Formula	C9H13N5
Canonical SMILES	CCC(C)N1C=NC2=C1N=CN=C2N
InChI	1S/C9H13N5/c1-3-6(2)14-5-13-7-8(10)11-4-12-9(7)14/h4-6H,3H2,1-2H3,(H2,10,11,12)
InChIKey	WUUGZXPFGNZPJO-UHFFFAOYSA-N
PubChem Compound ID	44572293
Target and Pathway
Target(s)	Adenosine A2a receptor	Target Info	Inhibitor	[530014]
	Adenosine A2b receptor	Target Info	Inhibitor	[530014]
KEGG Pathway	Rap1 signaling pathway
	Calcium signaling pathway
	cAMP signaling pathway
	Neuroactive ligand-receptor interaction
	Vascular smooth muscle contraction
	Parkinson's disease
	Alcoholismhsa04015:Rap1 signaling pathway
	Alcoholism
NetPath Pathway	TGF_beta_Receptor Signaling Pathway
	TCR Signaling Pathway
Pathway Interaction Database	HIF-2-alpha transcription factor networkcmyb_pathway:C-MYB transcription factor network
PathWhiz Pathway	Intracellular Signalling Through Adenosine Receptor A2a and AdenosinePW000446:Intracellular Signalling Through Adenosine Receptor A2b and Adenosine
Reactome	NGF-independant TRKA activation
	Adenosine P1 receptors
	G alpha (s) signalling events
	Surfactant metabolismR-HSA-417973:Adenosine P1 receptors
	Surfactant metabolism
WikiPathways	Nucleotide GPCRs
	Monoamine Transport
	GPCRs, Class A Rhodopsin-like
	NGF signalling via TRKA from the plasma membrane
	GPCR ligand binding
	GPCR downstream signaling
	GPCRs, OtherWP80:Nucleotide GPCRs
References
Ref 530014	Bioorg Med Chem. 2009 Apr 1;17(7):2812-22. Epub 2009 Feb 23.8-Bromo-9-alkyl adenine derivatives as tools for developing new adenosine A2A and A2B receptors ligands.
Ref 530014	Bioorg Med Chem. 2009 Apr 1;17(7):2812-22. Epub 2009 Feb 23.8-Bromo-9-alkyl adenine derivatives as tools for developing new adenosine A2A and A2B receptors ligands.

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