Drug General Information
Drug ID	D00MZS
Former ID	DNC001336
Drug Name	SK509
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[535405]
Structure		Download 2D MOL 3D MOL
Formula	C13H7Cl4NO2
Canonical SMILES	C1=CC=C(C=C1)NC(=O)C2=C(C(=C(C(=C2Cl)Cl)Cl)Cl)O
InChI	1S/C13H7Cl4NO2/c14-8-7(12(19)11(17)10(16)9(8)15)13(20)18-6-4-2-1-3-5-6/h1-5,19H,(H,18,20)
InChIKey	BDOBMVIEWHZYDL-UHFFFAOYSA-N
CAS Number	CAS 7426-07-5
PubChem Compound ID	124579
PubChem Substance ID	13451, 6610459, 10241118, 29304582, 57340979, 79336355, 103108848, 104421135, 117459832, 124403642, 126435467, 127500051, 134340536, 134340610, 135080950, 137244286, 162656379, 179315623, 227254214
Target and Pathway
Target(s)	Coagulation factor Xa	Target Info	Inhibitor	[535405]
KEGG Pathway	Complement and coagulation cascades
PANTHER Pathway	Blood coagulation
Pathway Interaction Database	Beta2 integrin cell surface interactions
PathWhiz Pathway	Coagulation
Reactome	Extrinsic Pathway of Fibrin Clot Formation
	Intrinsic Pathway of Fibrin Clot Formation
	Common Pathway of Fibrin Clot Formation
	Gamma-carboxylation of protein precursors
	Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus
	Removal of aminoterminal propeptides from gamma-carboxylated proteins
WikiPathways	Complement and Coagulation Cascades
	Human Complement System
	PTM: gamma carboxylation, hypusine formation and arylsulfatase activation
	Blood Clotting Cascade
	Formation of Fibrin Clot (Clotting Cascade)
References
Ref 535405	The design and synthesis of noncovalent factor Xa inhibitors. Curr Top Med Chem. 2001 Jun;1(2):137-49.
Ref 535405	The design and synthesis of noncovalent factor Xa inhibitors. Curr Top Med Chem. 2001 Jun;1(2):137-49.

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