Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D00PEU
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| Former ID |
DIB020731
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| Drug Name |
pirenperone
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| Synonyms |
R-47465
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent | Investigative | [1] | ||
| Structure |
|
Download2D MOL |
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| Formula |
C23H24FN3O2
|
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| InChI |
InChI=1S/C23H24FN3O2/c1-16-20(23(29)27-12-3-2-4-21(27)25-16)11-15-26-13-9-18(10-14-26)22(28)17-5-7-19(24)8-6-17/h2-8,12,18H,9-11,13-15H2,1H3
|
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| InChIKey |
HXCNRYXBZNHDNE-UHFFFAOYSA-N
|
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| PubChem Compound ID | |||||
| PubChem Substance ID |
855539, 5518524, 8152980, 10321799, 11111590, 11111591, 11341934, 11362117, 11364478, 11367040, 11369602, 11372728, 11374319, 11377764, 11466559, 11467679, 11485635, 11486198, 11487519, 11489496, 11491470, 11492435, 11495398, 14756637, 17405565, 24278110, 26612664, 26680560, 26746907, 26746908, 29223928, 46386967, 47207164, 47291338, 47440496, 47810995, 47959985, 48110691, 48185200, 48259470, 49698543, 50065155, 50100304, 50103904, 50103905, 50122680, 50122681, 52893072, 53778113, 56422490
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| Target and Pathway | |||||
| Target(s) | 5-hydroxytryptamine 7 receptor | Target Info | Antagonist | [2] | |
| KEGG Pathway | Ras signaling pathway | ||||
| Calcium signaling pathway | |||||
| Neuroactive ligand-receptor interaction | |||||
| Serotonergic synapse | |||||
| PANTHER Pathway | Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway | ||||
| PathWhiz Pathway | Excitatory Neural Signalling Through 5-HTR 7 and Serotonin | ||||
| Reactome | Serotonin receptors | ||||
| G alpha (s) signalling events | |||||
| WikiPathways | Serotonin Receptor 4/6/7 and NR3C Signaling | ||||
| Monoamine GPCRs | |||||
| GPCRs, Class A Rhodopsin-like | |||||
| GPCR ligand binding | |||||
| GPCR downstream signaling | |||||
| GPCRs, Other | |||||
| References | |||||
| REF 1 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 283). | ||||
| REF 2 | Cloning, expression and pharmacology of a truncated splice variant of the human 5-HT7 receptor (h5-HT7b). Br J Pharmacol. 1997 Sep;122(1):126-32. | ||||
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