Drug General Information
Drug ID	D00SPK
Former ID	DIB004276
Drug Name	E-4021
Drug Type	Small molecular drug
Indication	Cardiovascular disorder [ICD10:I00-I99]		Discontinued in Phase 2	[545643]
Company	Eisai Co Ltd
Structure		Download 2D MOL 3D MOL
Formula	C22H20ClN4NaO4
Canonical SMILES	c12c(nc(nc1ccc(c2)Cl)N1CCC(CC1)C(=O)[O-])NCc1cc2c(cc1)O<br />CO2.[Na+]
CAS Number	CAS 150452-18-9
PubChem Compound ID	23665864
Target and Pathway
Target(s)	CGMP-specific 3',5'-cyclic phosphodiesterase	Target Info	Inhibitor	[525427]
KEGG Pathway	Purine metabolism
	cGMP-PKG signaling pathway
NetPath Pathway	TGF_beta_Receptor Signaling Pathway
Reactome	cGMP effects
References
Ref 545643	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800004019)
Ref 525427	Potency and mechanism of action of E4021, a type 5 phosphodiesterase isozyme-selective inhibitor, on the photoreceptor phosphodiesterase depend on the state of activation of the enzyme. Mol Pharmacol. 1999 Mar;55(3):508-14.

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