Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D00TBJ
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| Former ID |
DIB014810
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| Drug Name |
PF-271836
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| Synonyms |
PF-271836; PF-2721374; PF-383965; PF-534422; PF-603059; UK-210587; UK-252820; UK-451402; Oxytocin antagonists (premature labor, prostatic hyperplasia, sexual dysfunction); Oxytocin antagonists (premature labor, prostatic hyperplasia, sexual dysfunction), Pfizer
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| Indication | Female sexual dysfunction [ICD9: 302.7; ICD10:F52] | Investigative | [1] | ||
| Company |
Pfizer Inc
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| Structure |
|
Download2D MOL |
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| Canonical SMILES |
c1(COCC)n(c(c2ccc(c(c2)C)OCC)nn1)c1ccc(nc1)OC
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| Target and Pathway | |||||
| Target(s) | Oxytocin receptor | Target Info | Antagonist | [1] | |
| KEGG Pathway | Calcium signaling pathway | ||||
| cAMP signaling pathway | |||||
| Neuroactive ligand-receptor interaction | |||||
| Oxytocin signaling pathway | |||||
| NetPath Pathway | TGF_beta_Receptor Signaling Pathway | ||||
| PANTHER Pathway | Oxytocin receptor mediated signaling pathway | ||||
| Reactome | Vasopressin-like receptors | ||||
| G alpha (q) signalling events | |||||
| WikiPathways | GPCRs, Class A Rhodopsin-like | ||||
| Myometrial Relaxation and Contraction Pathways | |||||
| Oxytocin signaling | |||||
| Gastrin-CREB signalling pathway via PKC and MAPK | |||||
| Peptide GPCRs | |||||
| GPCR ligand binding | |||||
| GPCR downstream signaling | |||||
| References | |||||
| REF 1 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 369). | ||||
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