Drug Information

Drug General Information
Drug ID
D00UTF
Former ID
DIB020575
Drug Name
NS5818
Synonyms
NS-5818
Drug Type
Small molecular drug
Indication Discovery agent Investigative [467612]
Structure
Download
2D MOL
Formula
C23H19Cl2N7O2
InChI
InChI=1S/C23H19Cl2N7O2/c1-32(2)22(33)14-5-3-13(4-6-14)19-8-7-17(12-20(19)21-28-30-31-29-21)26-23(34)27-18-10-15(24)9-16(25)11-18/h3-12H,1-2H3,(H2,26,27,34)(H,28,29,30,31)
InChIKey
FQIPXFVYNAMLDB-UHFFFAOYSA-N
PubChem Compound ID
69453339
PubChem Substance ID
178101092, 231295883
Target and Pathway
Target(s) ClC-7 Target Info Blocker (channel blocker) [531154]
References
Ref 467612(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4275).
Ref 531154The G215R mutation in the Cl-/H+-antiporter ClC-7 found in ADO II osteopetrosis does not abolish function but causes a severe trafficking defect. PLoS One. 2010 Sep 7;5(9):e12585.

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