Drug General Information
Drug ID
D00VKV
Former ID
DNC003501
Drug Name
Tenocyclidine
Drug Type
Small molecular drug
Indication Discovery agent Investigative [551400]
Structure
Download
2D MOL

3D MOL

Formula
C15H23NS
Canonical SMILES
C1CCC(CC1)(C2=CC=CS2)N3CCCCC3
InChI
1S/C15H23NS/c1-3-9-15(10-4-1,14-8-7-13-17-14)16-11-5-2-6-12-16/h7-8,13H,1-6,9-12H2
InChIKey
JUZZEWSCNBCFRL-UHFFFAOYSA-N
CAS Number
CAS 21500-98-1
PubChem Compound ID
PubChem Substance ID
Target and Pathway
Target(s) Glutamate [NMDA] receptor subunit epsilon 1 Target Info Antagonist [551400]
Glutamate [NMDA] receptor subunit epsilon 2 Target Info Antagonist [551400]
KEGG Pathway Ras signaling pathway
Rap1 signaling pathway
Calcium signaling pathway
cAMP signaling pathway
Neuroactive ligand-receptor interaction
Circadian entrainment
Long-term potentiation
Glutamatergic synapse
Dopaminergic synapse
Alzheimer's disease
Amyotrophic lateral sclerosis (ALS)
Cocaine addiction
Amphetamine addiction
Nicotine addiction
Alcoholism
Systemic lupus erythematosushsa04014:Ras signaling pathway
Huntington's disease
Systemic lupus erythematosus
PANTHER Pathway Huntington disease
Ionotropic glutamate receptor pathway
Metabotropic glutamate receptor group III pathway
Metabotropic glutamate receptor group I pathway
Muscarinic acetylcholine receptor 1 and 3 signaling pathwayP00029:Huntington disease
Muscarinic acetylcholine receptor 1 and 3 signaling pathway
Pathway Interaction Database Reelin signaling pathwayerbb4_pathway:ErbB4 signaling events
Reelin signaling pathway
Reactome Unblocking of NMDA receptor, glutamate binding and activation
CREB phosphorylation through the activation of CaMKII
Ras activation uopn Ca2+ infux through NMDA receptor
RAF/MAP kinase cascadeR-HSA-3928662:EPHB-mediated forward signaling
RAF/MAP kinase cascade
WikiPathways Hypothetical Network for Drug Addiction
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
Alzheimers DiseaseWP666:Hypothetical Network for Drug Addiction
BDNF signaling pathway
References
Ref 551400The binding of [3H]thienyl cyclohexylpiperidine ([3H]<span class="caps">TCP</span>) to the <span class="caps">NMDA</span>-phencyclidine receptor complex. Neuropharmacology. 1989 Jan;28(1):1-7.
Ref 551400The binding of [3H]thienyl cyclohexylpiperidine ([3H]<span class="caps">TCP</span>) to the <span class="caps">NMDA</span>-phencyclidine receptor complex. Neuropharmacology. 1989 Jan;28(1):1-7.

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