Drug General Information
Drug ID	D01BGW
Former ID	DNC006058
Drug Name	(2S)-1-(6-methoxy-1H-indazol-1-yl)propan-2-amine
Synonyms	(S)-2-(6-methoxyindazol-1-yl)-1-methylethylamine
Indication	Discovery agent		Investigative	[529168]
Structure		Download 2D MOL 3D MOL
Canonical SMILES	CC(CN1C2=C(C=CC(=C2)OC)C=N1)N
InChI	1S/C11H15N3O/c1-8(12)7-14-11-5-10(15-2)4-3-9(11)6-13-14/h3-6,8H,7,12H2,1-2H3/t8-/m0/s1
InChIKey	WSEWULCWBQDNEH-QMMMGPOBSA-N
Target and Pathway
Target(s)	5-hydroxytryptamine 2B receptor	Target Info	Inhibitor	[527952]
	5-hydroxytryptamine 2A receptor	Target Info	Inhibitor	[527952]
	5-hydroxytryptamine 2C receptor	Target Info	Inhibitor	[529168]
KEGG Pathway	Calcium signaling pathway
	Neuroactive ligand-receptor interaction
	Gap junction
	Serotonergic synapse
	Inflammatory mediator regulation of TRP channelshsa04020:Calcium signaling pathway
	Inflammatory mediator regulation of TRP channels
PANTHER Pathway	5HT2 type receptor mediated signaling pathwayP04374:5HT2 type receptor mediated signaling pathwayP04374:5HT2 type receptor mediated signaling pathway
Reactome	Serotonin receptors
	G alpha (q) signalling eventsR-HSA-390666:Serotonin receptors
	G alpha (q) signalling events
WikiPathways	Serotonin Receptor 2 and ELK-SRF/GATA4 signaling
	Monoamine GPCRs
	GPCRs, Class A Rhodopsin-like
	Gastrin-CREB signalling pathway via PKC and MAPK
	GPCR ligand binding
	GPCR downstream signalingWP733:Serotonin Receptor 2 and STAT3 Signaling
	SIDS Susceptibility Pathways
	GPCR downstream signaling
	GPCRs, OtherWP732:Serotonin Receptor 2 and ELK-SRF/GATA4 signaling
References
Ref 529168	Bioorg Med Chem. 2008 Feb 15;16(4):1966-82. Epub 2007 Nov 4.Synthesis and structure-activity relationships of a series of substituted 2-(1H-furo[2,3-g]indazol-1-yl)ethylamine derivatives as 5-HT2C receptor agonists.
Ref 527952	J Med Chem. 2006 Jan 12;49(1):318-28.1-((S)-2-aminopropyl)-1H-indazol-6-ol: a potent peripherally acting 5-HT2 receptor agonist with ocular hypotensive activity.
Ref 529168	Bioorg Med Chem. 2008 Feb 15;16(4):1966-82. Epub 2007 Nov 4.Synthesis and structure-activity relationships of a series of substituted 2-(1H-furo[2,3-g]indazol-1-yl)ethylamine derivatives as 5-HT2C receptor agonists.

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